A non-synthetic approach to extending the lifetime of hyperpolarized molecules using D(2)O solvation Journal Article
| Authors: | Cho, A.; Eskandari, R.; Miloushev, V. Z.; Keshari, K. R. |
| Article Title: | A non-synthetic approach to extending the lifetime of hyperpolarized molecules using D(2)O solvation |
| Abstract: | Although dissolution dynamic nuclear polarization is a robust technique to significantly increase magnetic resonance signal, the short T1 relaxation time of most 13C-nuclei limits the timescale of hyperpolarized experiments. To address this issue, we have characterized a non-synthetic approach to extend the hyperpolarized lifetime of 13C-nuclei in close proximity to solvent-exchangeable protons. Protons exhibit stronger dipolar relaxation than deuterium, so dissolving these compounds in D2O to exchange labile protons with solvating deuterons results in longer-lived hyperpolarization of the 13C-nucleus 2-bonds away. 13C T1 and T2 times were longer in D2O versus H2O for all molecules in this study. This phenomenon can be utilized to improve hyperpolarized signal-to-noise ratio as a function of longer T1, and enhanced spectral and imaging resolution via longer T2. © 2018 Elsevier Inc. |
| Keywords: | magnetic resonance; lifetime; molecules; signal to noise ratio; t1; deuterium; synthetic approach; hyperpolarization; t1 relaxation time; t2; dnp; imaging resolutions; deuterium compounds; dipolar relaxation; dissolution dynamics; exchangeable protons |
| Journal Title: | Journal of Magnetic Resonance |
| Volume: | 295 |
| ISSN: | 1090-7807 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2018-10-01 |
| Start Page: | 57 |
| End Page: | 62 |
| Language: | English |
| DOI: | 10.1016/j.jmr.2018.08.001 |
| PROVIDER: | scopus |
| PUBMED: | 30099234 |
| PMCID: | PMC6131049 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 September 2018 -- Source: Scopus |
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