Authors: | Dudakov, J. A.; van den Brink, M. R. M. |
Article Title: | Supply-side economics finds the thymus |
Abstract: | In this issue of Blood, Zlotoff and colleagues demonstrate that despite relaxed entry requirements after irradiation and hematopoietic stem cell transplantation (HSCT), insufficient supply of bone marrow (BM) T-cell progenitors acts as a limiting factor to thymic reconstitution,1 contributing toward delayed T-cell recovery. |
Keywords: | unclassified drug; note; t lymphocyte; bone marrow; cell maturation; hematopoietic stem cell transplantation; cell lineage; lymphocyte differentiation; immunological tolerance; myeloablative conditioning; pre t lymphocyte; thymus; irradiation; stroma; microenvironment; chemokine receptor; economic aspect; padgem protein; p selectin glycoprotein ligand 1; chemokine receptor ccr9; chemokine receptor ccl19; chemokine receptor ccl21; chemokine receptor ccl25; chemokine receptor ccr76; cytoreductive chemotherapy; immune reconstitution inflammatory syndrome; thrombocytopoiesis; thymopoiesis |
Journal Title: | Blood |
Volume: | 118 |
Issue: | 7 |
ISSN: | 0006-4971 |
Publisher: | American Society of Hematology |
Date Published: | 2011-08-18 |
Start Page: | 1715 |
End Page: | 1716 |
Language: | English |
DOI: | 10.1182/blood-2011-06-361337 |
PROVIDER: | scopus |
PUBMED: | 21852443 |
DOI/URL: | |
Notes: | --- - "Export Date: 3 October 2011" - "CODEN: BLOOA" - "Source: Scopus" |