Genomic profiles of glioma Journal Article
| Author: | Brennan, C. |
| Article Title: | Genomic profiles of glioma |
| Abstract: | Recent large-scale genomic profiling studies of glioma have yielded a proliferation of candidate subclasses, biomarkers and therapeutic targets for investigation. Some findings, such as that of IDH mutation in low-grade gliomas and secondary glioblastoma (GBM), fit well into established notions of different routes of gliomagenesis. Other results, such as the division of primary GBM based on signaling pathway alterations, suggest new pathogenetic routes with implications for treatment. The analysis of this data is still in the early stage. Nonetheless, several preliminary findings merit consideration in the development and interpretation of current clinical trials. © Springer Science+Business Media, LLC 2011. |
| Keywords: | vasculotropin; cancer survival; primary tumor; unclassified drug; gene mutation; sequence analysis; histopathology; cancer staging; glioma; cancer grading; cell proliferation; tumor differentiation; transcriptomics; phosphatidylinositol 3 kinase; protein p53; tumor marker; carcinogenesis; gene expression regulation; genome analysis; oncogene; tumor suppressor gene; diagnostic value; early cancer; glioblastoma; cyclin dependent kinase inhibitor 2a; egfr gene; cancer classification; neuropathology; isocitrate dehydrogenase; idh; isocitrate dehydrogenase 1; isocitrate dehydrogenase isoenzyme; molecular subclassification; tcga; cdkn2a gene; isocitrate dehydrogenase 1 gene; isocitrate dehydrogenase 2 gene |
| Journal Title: | Current Neurology and Neuroscience Reports |
| Volume: | 11 |
| Issue: | 3 |
| ISSN: | 1528-4042 |
| Publisher: | Springer |
| Date Published: | 2011-06-01 |
| Start Page: | 291 |
| End Page: | 297 |
| Language: | English |
| DOI: | 10.1007/s11910-011-0198-7 |
| PUBMED: | 21465149 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: CNNRB" - "Source: Scopus" |
