Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma Journal Article

   


Authors: Best, T.; Li, D.; Skol, A. D.; Kirchhoff, T.; Jackson, S. A.; Yasui, Y.; Bhatia, S.; Strong, L. C.; Domchek, S. M.; Nathanson, K. L.; Olopade, O. I.; Huang, R. S.; Mack, T. M.; Conti, D. V.; Offit, K.; Cozen, W.; Robison, L. L.; Onel, K.
Article Title: Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
Abstract: Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy-induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults. The variants comprise a risk locus associated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure. These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs. © 2011 Nature America, Inc. All rights reserved.
Keywords: adolescent; adult; child; controlled study; school child; major clinical study; protein function; gene expression; gene locus; genetic association; hodgkin disease; radiation exposure; cancer survivor; b lymphocyte induced maturation protein 1; gene interaction; chromosome 6q; radiation induced neoplasm; chromosome variant
Journal Title: Nature Medicine
Volume: 17
Issue: 8
ISSN: 1078-8956
Publisher: Nature Publishing Group  
Date Published: 2011-07-24
Start Page: 941
End Page: 943
Language: English
DOI: 10.1038/nm.2407
PROVIDER: scopus
PUBMED: 21785431
PMCID: PMC3229923
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79961155567&partnerID=40&md5=6ca4ce1c43a04c4ec104cc20e13a6c86
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 3 October 2011" - "CODEN: NAMEF" - "Source: Scopus"
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MSK Authors
  1. Kenneth Offit
    790 Offit
  2. Tomas Kirchhoff
    53 Kirchhoff
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