FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma Journal Article
| Authors: | Vogel, M. J.; Xie, L.; Guan, H.; Tooze, R. M.; Maier, T.; Kostezka, U.; Maier, H. J.; Holzmann, K.; Chan, F. C.; Steidl, C.; Reichel, J. B.; Weitzer, C. D.; Gehringer, F.; Kick, A. B.; Cesarman, E.; Roshal, M.; Gascoyne, R. D.; Möller, P.; Wirth, T.; Ushmorov, A. |
| Article Title: | FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma |
| Abstract: | The survival of classical Hodgkin lymphoma (cHL) cells depends on activation of NF-κB, JAK/STAT, and IRF4. Whereas these factors typically induce the master regulator of plasma cell (PC) differentiation PRDM1/BLIMP-1, levels of PRDM1 remain lowincHL.FOXO1,playingacritical roleinnormal B-celldevelopment,actsasatumor suppressorin cHL,buthasneverbeen associatedwithinductionof PCdifferentiation. Here we show that FOXO1 directly upregulates the full-length isoform PRDM1α in cHL cell lines. We also observed a positive correlation between FOXO1 and PRDM1 expression levels in primary Hodgkin-Reed-Sternberg cells. Further, we show that PRDM1α acts as a tumor suppressor in cHL at least partially by blocking MYC. Here we provide a link between FOXO1 repression and PRDM1α downregulation in cHL and identify PRDM1α as a tumor suppressor in cHL. The data support a potential role for FOXO transcription factors in normal PC differentiation. |
| Keywords: | controlled study; gene expression profiling; cell differentiation; tumor suppressor gene; plasma cell; nucleotide sequence; gene repression; down regulation; upregulation; oncogene myc; transcription factor fkhr; classical hodgkin lymphoma; reed sternberg cell; lymphoma cell line; article; b lymphocyte induced maturation gene 1alpha; foxo1 gene; primary cell |
| Journal Title: | Blood |
| Volume: | 124 |
| Issue: | 20 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2014-11-13 |
| Start Page: | 3118 |
| End Page: | 3129 |
| Language: | English |
| DOI: | 10.1182/blood-2014-07-590570 |
| PROVIDER: | scopus |
| PUBMED: | 25232062 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
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