Quantitative comparison of drug-induced amnesic effects: Choice of measures from a verbal learning task Conference Paper


Authors: Reinsel, R.; Veselis, R. A.; Dnistrian, A.; Duff, M.; Feshchenko, V. A.
Editors: Bonke, B.; Bovill, J. G.; Moerman, N.
Title: Quantitative comparison of drug-induced amnesic effects: Choice of measures from a verbal learning task
Conference Title: 3rd International Symposium on Memory and Awareness
Abstract: [suggest that] studies of drug-induced amnesia often use verbal-learning tasks, which offer a choice between several measures of memory performance / it is not clear which memory scores are most useful for quantifying drug-induced amnesia / determine empirically the answers to 4 questions / which of the commonly used sedative-hypnotic agents have the most amnesic potential / to what degree is memory impairment a function of serum concentration and sedative effects at the time of learning / can the slope of the function relating memory impairment to drug levels be used as an index of amnesic potency / which of the several available memory scores provides the most sensitive measure of drug-induced amnesia / 39 healthy, consenting volunteers (age range 21 to 45 yr) were randomised in a double-blind fashion to receive [midazolam, propofol, thiopentone or fentanyl with ondansetron pretreatment] (PsycINFO Database Record (c) 2016 APA, all rights reserved)
Keywords: serum concentration & sedative effects & amnesic potential of sedative-hypnotics & memory impairment on verbal-learning task; 21-45 yr olds; implications for sensitivity of memory tests
Journal Title Memory and Awareness in Anaesthesia III
Conference Dates: 1995 Jun
Conference Location: Rotterdam, Netherlands
ISBN: 90-232-3084-1
Publisher: Van Gorcum & Co  
Location: Assen, Netherlands
Date Published: 1996-01-01
Start Page: 71
End Page: 83
Language: English
ACCESSION: 1996-98478-009
PROVIDER: Ovid Technologies
PROVIDER: psycinfo
DOI/URL:
Notes: Book Chapter: 9 -- Source: PsycINFO
MSK Authors
  1. Robert A Veselis
    94 Veselis
  2. Ruth A Reinsel
    79 Reinsel