Sequelae of treatment in long-term survivors of testis cancer Journal Article
| Authors: | Abouassaly, R.; Fossa, S. D.; Giwercman, A.; Kollmannsberger, C.; Motzer, R. J.; Schmoll, H. J.; Sternberg, C. N. |
| Article Title: | Sequelae of treatment in long-term survivors of testis cancer |
| Abstract: | Context: Testicular cancer patients are often diagnosed at a young age, and because of the advances in the treatment of this disease, the vast majority have a normal life expectancy after therapy. Thus, recognition of the long-term sequelae of treatment (ie, surgery, radiation therapy, and chemotherapy) is particularly important in these patients. Objective: To review the adverse effects and the risk of secondary malignancy in long-term survivors of testicular cancer. Evidence acquisition: We conducted a Medline search to identify original articles and reviews on the long-term effects of testicular cancer treatment. Although the search included articles from January 1948 to February 2011, the majority of the included articles were published in the last two decades. Evidence synthesis: All studies examining the long-term sequelae of treatment in testicular cancer are retrospective in nature, with most classified as cohort, case-control, and/or epidemiologic studies. Given that no standardized method of reporting long-term complications exists, evidence synthesis is limited. Conclusions: Recent evidence suggests an increased risk of cardiovascular disease, neurotoxicity, and mild reductions in renal function in survivors of testicular cancer. Treatment of testicular malignancy can also negatively affect gonadal function and fertility and has been shown to result in an increased risk of solid malignancy and leukemia. © 2011 European Association of Urology. |
| Keywords: | cancer chemotherapy; treatment outcome; leukemia; review; cisplatin; cancer risk; hypertension; multimodality cancer therapy; solid tumor; antineoplastic agents; cancer radiotherapy; neurotoxicity; follow up; evidence-based medicine; neoplasms; c reactive protein; quality of life; lung toxicity; nephrotoxicity; etoposide; neuropathy; radiotherapy; incidence; morbidity; cd40 ligand; inflammation; risk factors; obesity; smoking; kidney failure; information retrieval; cancer therapy; vinblastine; high risk patient; time factors; cancer survivor; risk assessment; survivors; hypomagnesemia; lung embolism; endothelium cell; cytokine; body mass; hematologic malignancy; sexual dysfunction; drug accumulation; kidney injury; cardiovascular disease; cardiovascular risk; heart infarction; vein thrombosis; cardiovascular diseases; testicular neoplasms; blood vessel injury; radiation injuries; bleomycin; medline; platinum; glomerulus filtration rate; high density lipoprotein cholesterol; cholesterol blood level; dyslipidemia; insulin resistance; oxidative stress; drug blood level; hydrocortisone; orchiectomy; hypogonadism; cytokine release; inferior cava vein; disease predisposition; testis cancer; germ cell tumor; lung fibrosis; coronary artery disease; testosterone; life expectancy; seminoma; microalbuminuria; psychosocial disorder; electrolyte disturbance; raynaud phenomenon; endothelial dysfunction; male fertility; ototoxicity; nerve degeneration; atherogenesis; interstitial pneumonia; magnesium; chronic fatigue syndrome; kidney dysfunction; autonomic nervous system; infertility, male; testis nonseminoma cancer; bronchiolitis obliterans; germ cell and embryonal; apolipoprotein a1; apolipoprotein b; contralateral testicular cancer; dorsal root; gonad function; hydrocortisone urine level; male genital tract cancer; peripheral neuropraxia; thrombocyte aggregation; kidney diseases; neurotoxicity syndromes |
| Journal Title: | European Urology |
| Volume: | 60 |
| Issue: | 3 |
| ISSN: | 0302-2838 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2011-09-01 |
| Start Page: | 516 |
| End Page: | 526 |
| Language: | English |
| DOI: | 10.1016/j.eururo.2011.05.055 |
| PROVIDER: | scopus |
| PUBMED: | 21684072 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: EUURA" - "Source: Scopus" |
