Rat model of cardiotoxic drug-induced cardiomyopathy Journal Article
| Authors: | Nakahara, T.; Tanimoto, T.; Petrov, A. D.; Ishikawa, K.; Strauss, H. W.; Narula, J. |
| Article Title: | Rat model of cardiotoxic drug-induced cardiomyopathy |
| Abstract: | Cardiotoxicity from cancer drugs remains a clinical problem. To find reliable markers of cardiotoxicity, animal models were proposed and potential new diagnostic, markers have been actively investigated using these models. Here we describe our protocols, using male Sprague-Dawley rats, for inducing cardiomyopathy by single injection of high-dose doxorubicin (5–10, mg/kg) or multiple injections (2–4 times) of low-dose doxorubicin (2.5, mg/kg) with combined single injection of trastuzumab (10, mg/kg). The cardiotoxicity is evaluated by imaging modalities (echocardiography and nuclear imaging), serum troponin levels, and histopathological analyses. © Springer Science+Business Media, LLC, part of Springer Nature 2018. |
| Keywords: | doxorubicin; cardiotoxicity; echocardiography; left ventricular ejection fraction; troponin; traszmab |
| Journal Title: | Methods in Molecular Biology |
| Volume: | 1816 |
| ISSN: | 1064-3745 |
| Publisher: | Humana Press Inc |
| Date Published: | 2018-01-01 |
| Start Page: | 221 |
| End Page: | 232 |
| Language: | English |
| DOI: | 10.1007/978-1-4939-8597-5_17 |
| PROVIDER: | scopus |
| PUBMED: | 29987823 |
| DOI/URL: | |
| Notes: | Book Chapter 17 in "Experimental Models of Cardiovascular Diseases: Methods and Protocol" (ISBN: 978-1-4939-8596-8) -- Export Date: 1 August 2018 -- Source: Scopus |
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