The role of adjuvant treatment in early-stage oral cavity squamous cell carcinoma: An international collaborative study Journal Article
| Authors: | Fridman, E.; Na'ara, S.; Agarwal, J.; Amit, M.; Bachar, G.; Villaret, A. B.; Brandao, J.; Cernea, C. R.; Chaturvedi, P.; Clark, J.; Ebrahimi, A.; Fliss, D. M.; Jonnalagadda, S.; Kohler, H. F.; Kowalski, L. P.; Kreppel, M.; Liao, C. T.; Patel, S. G.; Patel, R. S.; Robbins, K. T.; Shah, J. P.; Shpitzer, T.; Yen, T. C.; Zöller, J. E.; Gil, Z.; for the International Consortium for Outcome Research in Head and Neck Cancer |
| Article Title: | The role of adjuvant treatment in early-stage oral cavity squamous cell carcinoma: An international collaborative study |
| Abstract: | BACKGROUND: Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re-resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC. METHODS: Overall survival (OS), disease-specific survival, local-free survival, and disease-free survival rates were calculated with Kaplan-Meier analysis. RESULTS: Of 1257 patients with T1-2N0M0 disease, 33 (2.6%) had positive margins, and 205 (16.3%) had close margins. The 5-year OS rate was 80% for patients with clear margins, 52% for patients with close margins, and 63% for patients with positive margins (P <.0001). In a multivariate analysis, age, depth of invasion, and margins were independent predictors of outcome. Close margins were associated with a >2-fold increase in the risk of recurrence (P <.0001). The multivariate analysis revealed that adjuvant treatment significantly improved the outcomes of patients with close/positive margins (P =.002 to.03). CONCLUSIONS: Patients with stage I to II OCSCC and positive/close margins have poor long-term outcomes. For this population, adjuvant treatment may be associated with improved survival. Cancer 2018;124:2948-55. © 2018 American Cancer Society. © 2018 American Cancer Society |
| Keywords: | survival; squamous cell carcinoma; margins; oral cavity |
| Journal Title: | Cancer |
| Volume: | 124 |
| Issue: | 14 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2018-07-15 |
| Start Page: | 2948 |
| End Page: | 2955 |
| Language: | English |
| DOI: | 10.1002/cncr.31531 |
| PROVIDER: | scopus |
| PUBMED: | 29757457 |
| PMCID: | PMC6607430 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2018 -- Source: Scopus |
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