Quantification of dispersion of Gd-DTPA from the initial area of enhancement into the peritumoral zone of edema in brain tumors Journal Article
| Authors: | Pronin, I. N.; McManus, K. A.; Holodny, A. I.; Peck, K. K. ; Kornienko, V. N. |
| Article Title: | Quantification of dispersion of Gd-DTPA from the initial area of enhancement into the peritumoral zone of edema in brain tumors |
| Abstract: | To evaluate Gd-DTPA contrast enhancement of brain tumors over time and to describe the dispersion of contrast into the zone of peritumoral edema. We performed MR imaging with a dose of 0.4 mmol Gd-DTPA/kg on eleven patients diagnosed with 5 different supratentorial tumors. MR imaging was done at five intervals between 5 min and 6 h. The change in zone of enhancement was measured for each time point, and a linear measurement was made of the furthest dispersion of contrast from the original volume of enhancement. An increase in the zone of enhancement over time was seen for all tumors; the average increase in volume of contrast was 14.76 ± 3.35 cm<sup>3</sup> (mean ± standard deviation). The largest changes in the zone of contrast enhancement, 18.6 ± 4.63 cm<sup>3</sup>, were seen in glioblastoma multiforme. The expansion of contrast enhancement assumed the morphology of the surrounding edema. The dispersion of Gd-DTPA over time into the zone of peritumoral edema is a potential source of error in clinical settings when there is a delay between Gd-DTPA injection and scanning. © Springer Science+Business Media, LLC. 2009. |
| Keywords: | adult; clinical article; aged; middle aged; gadolinium; nuclear magnetic resonance imaging; brain tumor; glioma; neurosurgery; brain neoplasms; magnetic resonance imaging; linear models; time factors; drug distribution; quantitative analysis; contrast enhancement; glioblastoma; contrast media; meningioma; brain mapping; image processing, computer-assisted; gadolinium pentetate; gadolinium dtpa; astrocytoma; brain edema; brain tumors |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 94 |
| Issue: | 3 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 2009-09-01 |
| Start Page: | 399 |
| End Page: | 408 |
| Language: | English |
| DOI: | 10.1007/s11060-009-9872-x |
| PUBMED: | 19330483 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: JNODD" - "Source: Scopus" |
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