Targeting the DNA damage response for cancer therapy Journal Article
| Authors: | Powell, S. N.; Bindra, R. S. |
| Article Title: | Targeting the DNA damage response for cancer therapy |
| Abstract: | Human tumors frequently have defects in the maintenance of genomic integrity, which involve a loss of the appropriate response to DNA damage. These pathways of genome integrity include key proteins involved in cell cycle checkpoints, histone modifications, and DNA repair. In this review, we discuss opportunities for therapeutic intervention by exploiting these defects, with an emphasis on those processes which are primarily associated with the repair of double-strand breaks. As these defects are specific to tumor cells, the development of new anti-cancer agents targeting these pathways may have an enhanced therapeutic window, with limited normal tissue toxicity. © 2009 Elsevier B.V. All rights reserved. |
| Keywords: | nonhuman; dna damage; homologous recombination; cell cycle; dna repair; cancer therapy; hypoxia; cancer genetics; tumor suppressor gene; double stranded dna; dna modification; chromatin; tumor cell; dna damage response; double stranded dna break; checkpoints; double-strand break repair; non-homologous end joining; single-strand break repair; tumor micro-environment |
| Journal Title: | DNA Repair |
| Volume: | 8 |
| Issue: | 9 |
| ISSN: | 1568-7864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-09-02 |
| Start Page: | 1153 |
| End Page: | 1165 |
| Language: | English |
| DOI: | 10.1016/j.dnarep.2009.04.011 |
| PROVIDER: | scopus |
| PUBMED: | 19501553 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 30 November 2010" - "CODEN: DRNEA" - "Source: Scopus" |
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