DNA repair and synthetic lethality Journal Article


Authors: Guo, G. S.; Zhang, F. M.; Gao, R. J.; Delsite, R.; Feng, Z. H.; Powell, S. N.
Article Title: DNA repair and synthetic lethality
Abstract: Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability to the synthetic lethality approach, which may lead to new therapeutic strategies. It is well known that poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitors show the synthetically lethal effect in tumors defective in BRCA1 or BRCA2 genes encoded proteins that are required for efficient HR. In this review, we summarize the strategies of targeting DNA repair pathways and other DNA metabolic functions to cause synthetic lethality in HR-defective tumor cells.
Keywords: homologous recombination; dna repair; tumors; brca; brca2; checkpoint; breast-cancer; cells; inhibition; strategy; synthetic lethality; rad52; polymerase; homologous recombination repair
Journal Title: International Journal of Oral Science
Volume: 3
Issue: 4
ISSN: 1674-2818
Publisher: Sichuan Univ  
Date Published: 2011-01-01
Start Page: 176
End Page: 179
Language: English
ACCESSION: WOS:000296282500002
DOI: 10.4248/ijos11064
PROVIDER: wos
PMCID: PMC3469974
PUBMED: 22010575
Notes: --- - Review - "Source: Wos"
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  1. Simon Nicholas Powell
    335 Powell
  2. Robert Lee Delsite
    12 Delsite