Mass spectrometry methods for detecting monoclonal immunoglobulins in multiple myeloma minimal residual disease Journal Article
| Author: | Thoren, K. L. |
| Article Title: | Mass spectrometry methods for detecting monoclonal immunoglobulins in multiple myeloma minimal residual disease |
| Abstract: | Mass spectrometry methods that can detect low levels of monoclonal immunoglobulin in serum have recently been developed. These assays are based on the principle that each immunoglobulin has a unique amino acid sequence and therefore, has a unique mass. This mass can be used as a surrogate marker in order to monitor a patient's disease over time and at low levels. Here, we explain these methods, discuss their advantages and disadvantages and how they may be used to monitor monoclonal immunoglobulins for minimal residual disease detection in multiple myeloma. © 2018 Elsevier Inc. |
| Keywords: | mass spectrometry; multiple myeloma; immunoglobulin; minimal residual disease |
| Journal Title: | Seminars in Hematology |
| Volume: | 55 |
| Issue: | 1 |
| ISSN: | 0037-1963 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2018-01-01 |
| Start Page: | 41 |
| End Page: | 43 |
| Language: | English |
| DOI: | 10.1053/j.seminhematol.2018.02.008 |
| PROVIDER: | scopus |
| PUBMED: | 29759153 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 June 2018 -- Source: Scopus |
