Novel methods for reporting of exercise dose and adherence: An exploratory analysis Journal Article


Authors: Nilsen, T. S.; Scott, J. M.; Michalski, M.; Capaci, C.; Thomas, S.; Herndon, J. E. 2nd; Sasso, J.; Eves, N. D.; Jones, L. W.
Article Title: Novel methods for reporting of exercise dose and adherence: An exploratory analysis
Abstract: Purpose The purpose of this study was to explore whether methods adapted from oncology pharmacological trials have utility in reporting adherence (tolerability) of exercise treatment in cancer. Methods Using a retrospective analysis of a randomized trial, 25 prostate cancer patients received an aerobic training regimen of 72 supervised treadmill walking sessions delivered thrice weekly between 55% and 100% of exercise capacity for 24 consecutive weeks. Treatment adherence (tolerability) was assessed using conventional (lost to follow-up and attendance) and exploratory (e.g., permanent discontinuation, dose modification, and relative dose intensity) outcomes. Results The mean total cumulative "planned" and "completed" dose was 200.7 ± 47.6 and 153.8 ± 68.8 MET·h, respectively, equating to a mean relative dose intensity of 77% ± 24%. Two patients (8%) were lost to follow-up, and mean attendance was 79%. A total of 6 (24%) of 25 patients permanently discontinued aerobic training before week 24. Aerobic training was interrupted (missing ≥3 consecutive sessions) or dose reduced in a total of 11 (44%) and 24 (96%) patients, respectively; a total 185 (10%) of 1800 training sessions required dose reduction owing to both health-related (all nonserious) and non-health-related adverse events. Eighteen (72%) patients required at least one session to be terminated early; a total of 59 (3%) sessions required early termination. Conclusions Novel methods for the conduct and reporting of exercise treatment adherence and tolerability may provide important information beyond conventional metrics in patients with cancer. Copyright © 2018 by the American College of Sports Medicine.
Keywords: prostate cancer; safety; tolerability; cancer; exercise oncology; training dose
Journal Title: Medicine and Science in Sports and Exercise
Volume: 50
Issue: 6
ISSN: 0195-9131
Publisher: Lippincott Williams & Wilkins  
Date Published: 2018-06-01
Start Page: 1134
End Page: 1141
Language: English
DOI: 10.1249/mss.0000000000001545
PROVIDER: scopus
PMCID: PMC5953772
PUBMED: 29315168
DOI/URL:
Notes: Article -- Export Date: 1 June 2018 -- Source: Scopus
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MSK Authors
  1. Lee Winston Jones
    143 Jones
  2. Jessica M Scott
    35 Scott
  3. Catherine Capaci
    4 Capaci