Nuclear imaging of cancer cell therapies Journal Article
| Author: | Ponomarev, V. |
| Article Title: | Nuclear imaging of cancer cell therapies |
| Abstract: | A promising role of cellular therapies in cancer treatment is reflected by the constantly growing number of clinical trials with adoptively transferred cells. Direct and indirect cell labeling for the nuclear imaging of transferred cells has been proven reliable for imaging adoptive cellular therapies. Both methods show their advantages and limitations. Direct labeling is a relatively easy, inexpensive, and well-established methodology. Indirect labeling using a reporter gene imaging paradigm allows for reliable, stable, and harmless visualization of cellular trafficking, persistence, proliferation, and function at the target site. It is expected that new human-derived reporter genes will be rapidly translated into clinical applications that require repetitive imaging for the effective monitoring of various genetic and cellular therapies. Copyright © 2009 by the Society of Nuclear Medicine, Inc. |
| Keywords: | unclassified drug; review; nonhuman; positron emission tomography; neoplasms; molecular imaging; oncology; biotechnology; cancer therapy; drug retention; drug uptake; isotope labeling; fluorodeoxyglucose f 18; computer assisted emission tomography; reporter gene; cell therapy; nuclear medicine; fialuridine i 124; tracer; single photon emission computer tomography; indium 111; molecular probe techniques; cell transfer; cell transplantation; 9 [4 fluoro 3 (hydroxymethyl)butyl]guanine f 18; pet/ct; cell labeling; 1 (2' deoxy 2' fluoroarabinofuranosyl)cytosine f 18; 8 quinolinol indium in 111; tomography, emission-computed |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 50 |
| Issue: | 7 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2009-07-01 |
| Start Page: | 1013 |
| End Page: | 1016 |
| Language: | English |
| DOI: | 10.2967/jnumed.109.064055 |
| PUBMED: | 19525449 |
| PROVIDER: | scopus |
| PMCID: | PMC4418529 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: JNMEA" - "Source: Scopus" |
