TET2 in normal and malignant hematopoiesis Journal Article
| Authors: | Bowman, R. L.; Levine, R. L. |
| Article Title: | TET2 in normal and malignant hematopoiesis |
| Abstract: | The ten-eleven translocation (TET) family of enzymes were originally cloned from the translocation breakpoint of t(10;11) in infant acute myeloid leukemia (AML) with subsequent genomic analyses revealing somatic mutations and suppressed expression of TET family members across a range of malignancies, particularly enriched in hematological neoplasms. The TET family of enzymes is responsible for the hydroxylation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosine (5-hmC), followed by active and passive mechanisms leading to DNA demethylation. Given the complexity and importance of DNA methylation events in cellular proliferation and differentiation, it comes as no surprise that the TET family of enzymes is intricately regulated by both small molecules and regulatory cooperating proteins. Here, we review the structure and function of TET2, its interactions with cooperating mutations and small molecules, and its role in aberrant hematopoiesis. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved. |
| Keywords: | dna binding protein; oncoprotein; tet2 protein, human; genetics; mutation; dna-binding proteins; proto-oncogene proteins; metabolism; cell differentiation; dna methylation; physiology; gene expression regulation; gene expression regulation, neoplastic; hematologic neoplasms; epigenesis, genetic; hematopoiesis; genetic epigenesis; oxidation reduction reaction; oxidation-reduction; hematologic disease; 5 methylcytosine; 5-methylcytosine; humans; human |
| Journal Title: | Cold Spring Harbor Perspectives in Medicine |
| Volume: | 7 |
| Issue: | 8 |
| ISSN: | 2157-1422 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2017-08-01 |
| Start Page: | a026518 |
| Language: | English |
| DOI: | 10.1101/cshperspect.a026518 |
| PUBMED: | 28242787 |
| PROVIDER: | scopus |
| PMCID: | PMC5538403 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 June 2018 -- Source: Scopus |
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