TET family proteins and their role in stem cell differentiation and transformation Journal Article

   

Authors:	Cimmino, L.; Abdel-Wahab, O.; Levine, R. L.; Aifantis, I.
Article Title:	TET family proteins and their role in stem cell differentiation and transformation
Abstract:	One of the main regulators of gene expression during embryogenesis and stem cell differentiation is DNA methylation. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its specialized enzymatic machinery and to understand the biological significance of 5hmC. The recent discovery of recurrent deletions and somatic mutations in the TET gene family, which includes proteins that can hydroxylate methylcytosine (5mC), in a large fraction of myeloid malignancies further suggested a key role for dynamic DNA methylation changes in the regulation of stem cell differentiation and transformation. © 2011 Elsevier Inc.
Keywords:	unclassified drug; dna binding protein; acute granulocytic leukemia; chronic myelomonocytic leukemia; somatic mutation; gene deletion; missense mutation; myeloproliferative disorder; myeloid metaplasia; review; nonhuman; dna replication; protein function; dna repair; protein dna binding; cell differentiation; mutational analysis; dna methylation; cell type; stem cell; gene mapping; hematologic malignancy; myelodysplastic syndrome; dna; deamination; dna modification; transcription regulation; epigenetics; cell transformation; leukemogenesis; hematopoietic stem cell; catalysis; thrombotic thrombocytopenic purpura; nonsense mutation; polycythemia vera; multigene family; protein tet2; 5 methylcytosine; hydroxylation; protein tet1; protein tet3; indel mutation
Journal Title:	Cell Stem Cell
Volume:	9
Issue:	3
ISSN:	1934-5909
Publisher:	Cell Press
Date Published:	2011-09-02
Start Page:	193
End Page:	204
Language:	English
DOI:	10.1016/j.stem.2011.08.007
PROVIDER:	scopus
PUBMED:	21885017
PMCID:	PMC3244690
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-80052303426&partnerID=40&md5=5fa02d91ed8820093078f90de4daeefb
Notes:	--- - "Export Date: 3 October 2011" - "Source: Scopus"

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