Renal cell carcinoma genetic analysis by comparative genomic hybridization and restriction fragment length polymorphism analysis Journal Article

  


Authors: Presti, J. C. Jr; Moch, H.; Reuter, V. E.; Cordon-Cardo, C.; Waldman, F. M.
Article Title: Renal cell carcinoma genetic analysis by comparative genomic hybridization and restriction fragment length polymorphism analysis
Abstract: Purpose: To compare comparative genomic hybridization (CGH) with restriction fragment length polymorphism (RFLP) analysis in renal cell carcinoma (RCC). Materials and Methods: Fifteen RCC specimens were analyzed by both CGH and RFLP analysis at 18 loci. Results: Restriction fragment length polymorphism analysis was informative on 90 chromosomal arms. Allelic imbalance was identified on 27 chromosomal arms by RFLP and on 26 arms by CGH. Data from CGH and RFLP demonstrated a high degree of concordance (p<0.001). Comparative genomic hybridization identified previously documented areas of interest in RCC as well as potential new areas of interest including loss of genetic material on chromosome 2 and gains of genetic material on chromosome 16p. Conclusions: Comparative genomic hybridization can successfully be performed in RCC specimens, As it surveys the entire genome simultaneously, it may be more efficient than conventional cytogenetics or RFLP analysis in analyzing RCC.
Keywords: genetics; kidney neoplasms; tumors; molecular analysis; deletion; human bladder-cancer
Journal Title: Journal of Urology
Volume: 156
Issue: 1
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1996-07-01
Start Page: 281
End Page: 285
Language: English
ACCESSION: WOS:A1996UQ31700095
DOI: 10.1016/s0022-5347(01)66017-8
PROVIDER: wos
PUBMED: 8648824
Notes: Article -- Source: Wos
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Victor Reuter
    1228 Reuter
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