Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy Journal Article
| Authors: | Zier, K.; Gansbacher, B.; Salvadori, S. |
| Article Title: | Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy |
| Abstract: | Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin I (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects. |
| Keywords: | interleukin-2; antigen receptor; expression; molecules; costimulation; protein-tyrosine kinase; zeta-chain; lymphocytes-t; lasting antitumor immunity; tumor-bearing mice |
| Journal Title: | Immunology Today |
| Volume: | 17 |
| Issue: | 1 |
| ISSN: | 0167-5699 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1996-01-01 |
| Start Page: | 39 |
| End Page: | 45 |
| Language: | English |
| ACCESSION: | WOS:A1996TQ01500014 |
| DOI: | 10.1016/0167-5699(96)80567-6 |
| PROVIDER: | wos |
| PUBMED: | 8652051 |
| Notes: | Review -- Source: Wos |
