Is intra-arterial chemotherapy worthwhile in the treatment of patients with unresectable hepatic colorectal cancer metastases? - Pro Journal Article
| Authors: | Cohen, A. M.; Kemeny, N. E. |
| Article Title: | Is intra-arterial chemotherapy worthwhile in the treatment of patients with unresectable hepatic colorectal cancer metastases? - Pro |
| Abstract: | Regional chemotherapy, from a theoretical and pharmacological stand point, would seem to offer significant-advantage over systemic therapy for the treatment of hepatic metastatic colorectal cancer patients. Clinical experience has shown us that the technique itself is fraught with practical problems, but over the years, specialist centres have learned to overcome many of these, making the technique safer and minimising the possibility of complications and toxicity. As a consequence, there is no doubt that high response rates can be achieved with HAI fluoropyrimidines. However, randomised data have only been obtained from small numbers of patients in suboptimally designed trials and, to date, true patient benefit in terms of either survival or quality of life has not been adequately demonstrated. In parallel with the U.S. Intergroup study, the U.K.-based MRC phase III clinical trial of regional versus systemic 5-FU/FA warrants urgent support and we would welcome collaboration with interested European and American centres. The outcome of this trial will fully define the role of HAI chemotherapy in the management of unresectable hepatic metastatic colorectal cancer, in the context of modern, modulated 5-FU. |
| Keywords: | cancer chemotherapy; cancer survival; controlled study; clinical trial; hepatitis; fluorouracil; drug efficacy; antineoplastic agents; liver neoplasms; antineoplastic agent; colorectal cancer; alpha2b interferon; controlled clinical trial; dexamethasone; carmustine; colorectal neoplasms; liver metastasis; cancer regression; randomized controlled trials; folinic acid; intraarterial drug administration; regional perfusion; infusions, intra-arterial; short survey; mitomycin; floxuridine; hepatic artery; intravenous drug administration; gastritis; peptic ulcer; humans; human; priority journal; intratumoral drug administration |
| Journal Title: | European Journal of Cancer |
| Volume: | 32A |
| Issue: | 13 |
| ISSN: | 0959-8049 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1996-12-01 |
| Start Page: | 2195 |
| End Page: | 2197 |
| Language: | English |
| DOI: | 10.1016/s0959-8049(96)00393-0 |
| PUBMED: | 9038600 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 23 May 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work