Regional Chemotherapy: A Focus on Hepatic Artery Infusion for Colorectal Cancer Liver Metastases Journal Article
| Authors: | Dizon, D. S.; Schwartz, J.; Kemeny, N. |
| Article Title: | Regional Chemotherapy: A Focus on Hepatic Artery Infusion for Colorectal Cancer Liver Metastases |
| Abstract: | Regional infusion strategies have been used as a treatment modality in multiple cancers, including ovarian, appendiceal, and colorectal cancers. Perhaps the most illustrative use of regional therapy is that of hepatic arterial infusion (HAI) for liver metastases from colorectal cancer. The administration of chemotherapy by HAI is logical and has theoretic advantages over systemic chemotherapy for the treatment of hepatic metastases from colorectal cancer. With the use of an appropriately chosen chemotherapy agent, HAI can generate an increase in hepatic tumor drug exposure as compared with intravenous delivery of the same agent. This article reviews the pharmacologic benefits of HAI therapy and the contemporary trials performed and underway. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; clinical trial; review; cisplatin; doxorubicin; fluorouracil; diarrhea; drug efficacy; drug safety; drug withdrawal; side effect; treatment planning; antineoplastic agents; clinical trials as topic; liver neoplasms; outcome assessment; anorexia; colorectal cancer; adenocarcinoma; liver toxicity; multiple cycle treatment; gastrointestinal symptom; dexamethasone; patient monitoring; continuous infusion; drug effect; necrosis; carmustine; irinotecan; aspartate aminotransferase blood level; colorectal neoplasms; fibrosis; survival time; liver metastasis; folinic acid; stomach ulcer; drug response; drug infusion; chemotherapy, cancer, regional perfusion; jaundice; mitomycin c; alkaline phosphatase blood level; hyperbilirubinemia; heartburn; drug half life; oxaliplatin; floxuridine; abdominal cramp; hepatic artery; cooperation; drug exposure; cholestasis; duodenum ulcer; drug choice; liver necrosis; dichloromethotrexate; cancer regional chemotherapy; chemical hepatitis; hepatic artery infusion; sclerosing cholangitis |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 17 |
| Issue: | 4 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-10-01 |
| Start Page: | 759 |
| End Page: | 771 |
| Language: | English |
| DOI: | 10.1016/j.soc.2008.04.009 |
| PUBMED: | 18722916 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: SOCAF" - "Source: Scopus" |
