The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors Journal Article

  


Authors: Rusch, V.; Mendelsohn, J.; Dmitrovsky, E.
Article Title: The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors
Abstract: The epidermal growth factor receptor (EGFR) is detected on many non- haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-α, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.
Keywords: human tissue; neoplasm; neoplasms; cell proliferation; animal; metabolism; animals; gene targeting; epidermal growth factor receptor; receptor, epidermal growth factor; drug effect; tumor cell culture; autophosphorylation; cancer therapy; animalia; monoclonal antibody; drug receptor binding; gene expression regulation; gene expression regulation, neoplastic; antibodies, monoclonal; chemistry; tissue distribution; cell transformation; hematopoietic cell; ligands; short survey; conformational transition; egfr; therapeutic targets; ligand binding; transforming growth factor alpha; human tumors; humans; human
Journal Title: Cytokine & Growth Factor Reviews
Volume: 7
Issue: 2
ISSN: 1359-6101
Publisher: Elsevier Science, Inc.  
Date Published: 1996-08-01
Start Page: 133
End Page: 141
Language: English
DOI: 10.1016/1359-6101(96)00016-0
PUBMED: 8899291
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030206987&doi=10.1016%2f1359-6101%2896%2900016-0&partnerID=40&md5=27b014f49aa2cc978eaec5aa613b12c5
Notes: Short Survey -- Export Date: 23 May 2018 -- Source: Scopus
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MSK Authors
  1. Valerie W Rusch
    864 Rusch
  2. Ethan Dmitrovsky
    98 Dmitrovsky
  3. John Mendelsohn
    128 Mendelsohn
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