Matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer invasion, metastases, and prognosis Journal Article

  


Authors: Guillem, J. G.; Murray, M. P.; Zeng, Z. S.; Kuranami, M.; Swallow, C. J.; Mansilla-Soto, J.
Article Title: Matrix metalloproteinases and tissue inhibitor of metalloproteinases in colorectal cancer invasion, metastases, and prognosis
Abstract: Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases that are capable of proteolytic degradation of the extracellular matrix and basement membrane and have been implicated in tumor invasion and metastasis. In this article, we will briefly review the MMP family and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs), as well as review in vitro and in vivo evidence supporting a role for MMPs and TIMPs in cancer invasion and metastasis, in particular colorectal cancer. In addition, we will address the potential role of MMPs as markers of colorectal cancer prognosis and their potential use as novel target molecules for antimetastatic therapy.
Keywords: treatment outcome; review; pathophysiology; cancer staging; colorectal cancer; metastasis; basement membrane; enzyme activity; structure activity relation; prediction; risk assessment; cancer invasion; extracellular matrix; sequence homology; collagenase; stromelysin; matrilysin; gelatinase; metalloproteinase inhibitor; prognosis
Journal Title: Seminars in Colon and Rectal Surgery
Volume: 7
Issue: 1
ISSN: 1043-1489
Publisher: Elsevier Inc.  
Date Published: 1996-03-01
Start Page: 31
End Page: 39
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029979650&partnerID=40&md5=f277da8e3b904bb8b780d53341c0eb0c
Notes: Review -- Export Date: 22 November 2017 -- Source: Scopus