Bacterial protein toxins and cell vesicle trafficking Journal Article
| Authors: | Montecucco, C.; Papini, E.; Schiavo, G. |
| Article Title: | Bacterial protein toxins and cell vesicle trafficking |
| Abstract: | A group of bacterial protein toxins interfere with vesicular trafficking inside cells. Clostridial neurotoxins affect mainly the highly regulated fusion of neurotransmitter- and hormone-containing vesicles with the plasma membrane. They cleave the three SNARE proteins: VAMP, SNAP-25 and syntaxin, and this selective proteolysis results in a blockade of exocytosis. The Helicobacter pylori cytotoxin is implicated in the pathogenesis of gastroduodenal ulcers. It causes a progressive and extensive vacuolation of cells followed by necrosis, after a cytotoxin-induced alteration of membrane trafficking by late endosomes. Vacuoles originate from this compartment in a rab7-dependent process and swell because they are acidic and accumulate membrane-permeant amines. |
| Keywords: | review; models, biological; protein degradation; nerve tissue proteins; membrane proteins; bacterial protein; cell membrane; protein transport; hormone; helicobacter pylori; clostridium toxin; exocytosis; tetanus; cell vacuole; vesicular transport proteins; cytotoxin; proteases; membrane fusion; peptic ulcer; botulinum toxin; endosomes; syntaxin; neurotransmitter; bacterial toxins; qa-snare proteins; snare proteins; synaptosomal-associated protein 25; bacterial toxin; synaptobrevin; neurotoxin; neurotoxins; botulism; tetanus toxin; gastroduodenal ulcer |
| Journal Title: | Experientia |
| Volume: | 52 |
| Issue: | 12 |
| ISSN: | 0014-4754 |
| Publisher: | Birkhaeuser Science |
| Date Published: | 1996-12-16 |
| Start Page: | 1026 |
| End Page: | 1032 |
| Language: | English |
| DOI: | 10.1007/bf01952098 |
| PUBMED: | 8988242 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 22 November 2017 -- Source: Scopus |
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