Management of important adverse events associated with inotuzumab ozogamicin: Expert panel review Journal Article


Authors: Kebriaei, P.; Cutler, C.; de Lima, M.; Giralt, S.; Lee, S. J.; Marks, D.; Merchant, A.; Stock, W.; van Besien, K.; Stelljes, M.
Article Title: Management of important adverse events associated with inotuzumab ozogamicin: Expert panel review
Abstract: Inotuzumab ozogamicin (InO), a humanized anti-CD22 monoclonal antibody conjugated to the cytotoxic antibiotic agent calicheamicin, has demonstrated efficacy in the phase 3 INO-VATE study of adults with relapsed or refractory acute lymphoblastic leukemia (ALL). Findings from the study showed clinically important adverse events (AEs) associated with InO, with veno-occlusive disease (VOD) reported as a major non-hematologic AE. Other important or serious AEs include neutropenia, febrile neutropenia, thrombocytopenia, infusion-related reactions, tumor lysis syndrome, and prolonged QT syndrome. This report summarizes the recommendations of an expert panel of hematologists and transplant physicians for evaluation and management of the important AEs associated with InO, with a focus on diagnosis, prevention, monitoring, and management of VOD. The possible interventions considered included prophylaxis medications, patient monitoring and assessment, and InO dose adjustment or discontinuation. © 2017 Macmillan Publishers Ltd., part of Springer Nature.
Journal Title: Bone Marrow Transplantation
Volume: 53
Issue: 4
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2018-04-01
Start Page: 449
End Page: 456
Language: English
DOI: 10.1038/s41409-017-0019-y
PROVIDER: scopus
PUBMED: 29330398
DOI/URL:
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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MSK Authors
  1. Sergio Andres Giralt
    500 Giralt