TGF-β inhibition and immunotherapy: Checkmate Journal Article
| Authors: | Ganesh, K.; Massagué, J. |
| Article Title: | TGF-β inhibition and immunotherapy: Checkmate |
| Abstract: | Immune checkpoint therapy can induce durable remissions, but many tumors demonstrate resistance. In a recent issue of Nature, Mariathasan et al. (2018) and Tauriello et al. (2018) identify stromal TGF-β signaling as a determinant of immune exclusion. Combination TGF-β inhibition and immunotherapy induces complete responses in mouse models. Immune checkpoint therapy can induce durable remissions, but many tumors demonstrate resistance. In a recent issue of Nature, Mariathasan et al. (2018) and Tauriello et al. (2018) identify stromal TGF-β signaling as a determinant of immune exclusion. Combination TGF-β inhibition and immunotherapy induces complete responses in mouse models. © 2018 Elsevier Inc. |
| Keywords: | nonhuman; colorectal cancer; cd8+ t lymphocyte; biological marker; phenotype; cancer immunotherapy; melanoma; metastasis; tumor volume; transforming growth factor beta; tumor biopsy; tumor regression; cancer regression; microsatellite instability; cd4+ t lymphocyte; drug response; short survey; cytotoxic t lymphocyte antigen 4; programmed death 1 ligand 1; non small cell lung cancer; tumor microenvironment; metastatic colorectal cancer; human; priority journal; atezolizumab; solid malignant neoplasm; tgf beta signaling; galunisertib |
| Journal Title: | Immunity |
| Volume: | 48 |
| Issue: | 4 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2018-04-17 |
| Start Page: | 626 |
| End Page: | 628 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2018.03.037 |
| PROVIDER: | scopus |
| PUBMED: | 29669246 |
| PMCID: | PMC6347120 |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 1 May 2018 -- Source: Scopus |
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