Androgen-deprivation therapy, dementia, and cognitive dysfunction in men with prostate cancer: How much smoke and how much fire? Journal Article


Authors: McHugh, D. J.; Root, J. C.; Nelson, C. J.; Morris, M. J.
Article Title: Androgen-deprivation therapy, dementia, and cognitive dysfunction in men with prostate cancer: How much smoke and how much fire?
Abstract: Androgen-deprivation therapy (ADT) remains the cornerstone of management for patients with metastatic prostate cancer. Although the toxicities of ADT are well established, there is increasing controversy surrounding the association between cognitive dysfunction and the receipt of ADT, with some evidence suggesting an increased risk of dementia. The authors conducted a literature search to identify pertinent clinical studies in this field. This general review outlines the key findings and discusses the relative strengths and weaknesses when drawing conclusions about the risk of cognitive dysfunction or dementia with ADT use. Cancer 2018;124:1326-34. © 2018 American Cancer Society. © 2018 American Cancer Society
Keywords: prostate cancer; dementia; cognitive dysfunction; androgen deprivation; alzheimer's dementia
Journal Title: Cancer
Volume: 124
Issue: 7
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2018-04-01
Start Page: 1326
End Page: 1334
Language: English
DOI: 10.1002/cncr.31153
PROVIDER: scopus
PMCID: PMC5885282
PUBMED: 29338083
DOI/URL:
Notes: Review -- Export Date: 1 May 2018 -- Source: Scopus
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MSK Authors
  1. Michael Morris
    274 Morris
  2. James Charles Root
    42 Root
  3. Christian Nelson
    254 Nelson
  4. Deaglan Joseph McHugh
    4 McHugh