Adult height is associated with increased risk of ovarian cancer: A Mendelian randomisation study Journal Article


Authors: Dixon-Suen, S. C.; Nagle, C. M.; Thrift, A. P.; Pharoah, P. D. P.; Ewing, A.; Pearce, C. L.; Zheng, W.; Australian Ovarian Cancer Study Group; Chenevix-Trench, G.; Fasching, P. A.; Beckmann, M. W.; Lambrechts, D.; Vergote, I.; Lambrechts, S.; Van Nieuwenhuysen, E.; Rossing, M. A.; Doherty, J. A.; Wicklund, K. G.; Chang-Claude, J.; Jung, A. Y.; Moysich, K. B.; Odunsi, K.; Goodman, M. T.; Wilkens, L. R.; Thompson, P. J.; Shvetsov, Y. B.; Dörk, T.; Park-Simon, T. W.; Hillemanns, P.; Bogdanova, N.; Butzow, R.; Nevanlinna, H.; Pelttari, L. M.; Leminen, A.; Modugno, F.; Ness, R. B.; Edwards, R. P.; Kelley, J. L.; Heitz, F.; du Bois, A.; Harter, P.; Schwaab, I.; Karlan, B. Y.; Lester, J.; Orsulic, S.; Rimel, B. J.; Kjær, S. K.; Høgdall, E.; Jensen, A.; Goode, E. L.; Fridley, B. L.; Cunningham, J. M.; Winham, S. J.; Giles, G. G.; Bruinsma, F.; Milne, R. L.; Southey, M. C.; Hildebrandt, M. A. T.; Wu, X.; Lu, K. H.; Liang, D.; Levine, D. A.; Bisogna, M.; Schildkraut, J. M.; Berchuck, A.; Cramer, D. W.; Terry, K. L.; Bandera, E. V.; Olson, S. H.; Salvesen, H. B.; Thomsen, L. C. V.; Kopperud, R. K.; Bjorge, L.; Kiemeney, L. A.; Massuger, L. F. A. G.; Pejovic, T.; Bruegl, A.; Cook, L. S.; Le, N. D.; Swenerton, K. D.; Brooks-Wilson, A.; Kelemen, L. E.; Lubiński, J.; Huzarski, T.; Gronwald, J.; Menkiszak, J.; Wentzensen, N.; Brinton, L.; Yang, H.; Lissowska, J.; Høgdall, C. K.; Lundvall, L.; Song, H.; Tyrer, J. P.; Campbell, I.; Eccles, D.; Paul, J.; Glasspool, R.; Siddiqui, N.; Whittemore, A. S.; Sieh, W.; McGuire, V.; Rothstein, J. H.; Narod, S. A.; Phelan, C.; Risch, H. A.; McLaughlin, J. R.; Anton-Culver, H.; Ziogas, A.; Menon, U.; Gayther, S. A.; Ramus, S. J.; Gentry-Maharaj, A.; Wu, A. H.; Pike, M. C.; Tseng, C. C.; Kupryjanczyk, J.; Dansonka-Mieszkowska, A.; Budzilowska, A.; Rzepecka, I. K.; Webb, P. M.; on behalf of the Ovarian Cancer Association Consortium
Article Title: Adult height is associated with increased risk of ovarian cancer: A Mendelian randomisation study
Abstract: Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Results: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. Conclusions: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis. © 2018 Cancer Research UK.
Journal Title: British Journal of Cancer
Volume: 118
Issue: 8
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2018-04-01
Start Page: 1123
End Page: 1129
Language: English
DOI: 10.1038/s41416-018-0011-3
PROVIDER: scopus
PUBMED: 29555990
PMCID: PMC5931085
DOI/URL:
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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  2. Sara H Olson
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