Challenges in validating candidate therapeutic targets in cancer Journal Article
| Authors: | Settleman, J.; Sawyers, C. L.; Hunter, T. |
| Article Title: | Challenges in validating candidate therapeutic targets in cancer |
| Abstract: | More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not. These reports highlight the caveats associated with some of the research tools that are commonly used to validate candidate therapeutic targets in cancer research. © Settleman et al. |
| Keywords: | cell proliferation; phenotype; cell death; gene expression; rna interference; cytotoxicity; attention; genetic heterogeneity; human; article; malignant neoplasm |
| Journal Title: | eLife |
| Volume: | 7 |
| ISSN: | 2050-084X |
| Publisher: | eLife Sciences Publications Ltd. |
| Date Published: | 2018-02-08 |
| Start Page: | e32402 |
| Language: | English |
| DOI: | 10.7554/eLife.32402 |
| PROVIDER: | scopus |
| PMCID: | PMC5805407 |
| PUBMED: | 29417929 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 April 2018 -- Source: Scopus |
