Multimodality imaging using proton magnetic resonance spectroscopic imaging and (18)F-fluorodeoxyglucose-positron emission tomography in local prostate cancer Journal Article
| Authors: | Shukla-Dave, A.; Wassberg, C.; Pucar, D.; Schöder, H.; Goldman, D. A.; Mazaheri, Y.; Reuter, V. E.; Eastham, J.; Scardino, P. T.; Hricak, H. |
| Article Title: | Multimodality imaging using proton magnetic resonance spectroscopic imaging and (18)F-fluorodeoxyglucose-positron emission tomography in local prostate cancer |
| Abstract: | AIM To assess the relationship using multimodality imaging between intermediary citrate/choline metabolism as seen on proton magnetic resonance spectroscopic imaging (H-1-MRSI) and glycolysis as observed on F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG-PET/CT) in prostate cancer (PCa) patients. METHODS The study included 22 patients with local PCa who were referred for endorectal magnetic resonance imaging/H-1-MRSI (April 2002 to July 2007) and F-18-FDG-PET/CT and then underwent prostatectomy as primary or salvage treatment. Whole-mount step-section pathology was used as the standard of reference. We assessed the relationships between PET parameters standardized uptake value (SUVmax and SUVmean)] and MRSI parameters [choline + crea-tine/citrate (CC/Cmax and CC/Cmean) and total number of suspicious voxels] using spearman's rank correlation, and the relationships of PET and H-1-MRSI index lesion parameters to surgical Gleason score. RESULTS Abnormal intermediary metabolism on H-1-MRSI was present in 21/22 patients, while abnormal glycolysis on F-18-FDG-PET/CT was detected in only 3/22 patients. Specifically, index tumor localization rates were 0.95 (95% CI: 0.77-1.00) for H-1-MRSI and 0.14 (95% CI: 0.03-0.35) for F-18-FDG-PET/CT. Spearman rank correlations indicated little relationship (rho = -0.36-0.28) between H-1-MRSI parameters and F-18-FDG-PET/CT parameters. Both the total number of suspicious voxels (rho = 0.55, P = 0.0099) and the SUVmax (rho = 0.46, P = 0.0366) correlated weakly with the Gleason score. No significant relationship was found between the CC/Cmax, CC/Cmean or SUVmean and the Gleason score (P = 0.15-0.79). CONCLUSION The concentration of intermediary metabolites detected by H-1 MRSI and glycolytic flux measured F-18-FDG PET show little correlation. Furthermore, only few tumors were FDG avid on PET, possibly because increased glycolysis represents a late and rather ominous event in the progression of PCa. |
| Keywords: | survival; prostate cancer; radical prostatectomy; akt; pet/ct; transformation; radiation-therapy; prognostic value; cell-growth; pathological analysis; atp-citrate lyase; proton magnetic resonance spectroscopic imaging; f-18-fluorodeoxyglucose-positron emission tomography |
| Journal Title: | World Journal of Radiology |
| Volume: | 9 |
| Issue: | 3 |
| ISSN: | 1949-8470 |
| Publisher: | Baishideng Publishing Group Inc |
| Date Published: | 2017-03-28 |
| Start Page: | 134 |
| End Page: | 142 |
| Language: | English |
| ACCESSION: | WOS:000424414600005 |
| DOI: | 10.4329/wjr.v9.i3.134 |
| PROVIDER: | wos |
| PMCID: | PMC5368629 |
| PUBMED: | 28396727 |
| Notes: | Article -- Source: Wos |
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