Renal masses detected on FDG PET/CT in patients with lymphoma: Imaging features differentiating primary renal cell carcinomas from renal lymphomatous involvement Journal Article


Authors: Nicolau, C.; Sala, E.; Kumar, A.; Goldman, D. A.; Schoder, H.; Hricak, H.; Vargas, H. A.
Article Title: Renal masses detected on FDG PET/CT in patients with lymphoma: Imaging features differentiating primary renal cell carcinomas from renal lymphomatous involvement
Abstract: OBJECTIVE. The purpose of this study is to analyze the 18F-FDG PET/CT features of solid renal masses detected in patients with lymphoma and to evaluate the ability of PET/CT to differentiate renal cell carcinoma (RCC) from renal lymphomatous involvement. MATERIALS AND METHODS. Thirty-six patients with solid renal masses on PET/CT performed for staging or follow-up of lymphoma were evaluated retrospectively. The features recorded for each renal mass included the following standardized uptake values (SUVs) on PET/CT: the maximum SUV (SUVmax), the mean SUV (SUVmean), the ratio of the SUVmax of the tumor to that of the normal kidney cortex, the ratio of the SUVmean of the tumor to that of the normal kidney cortex, the ratio of the SUVmax of the tumor to that of the normal liver, and the ratio of the SUVmean of the tumor to that of the normal liver. Renal mass size and margins (well defined vs infiltrative) and the presence of calcifications were evaluated on CT. Renal biopsy results were used as the reference standard. Relationships between imaging parameters and histopathologic findings were assessed. RESULTS. Of the 36 renal masses evaluated, 22 (61.1%) were RCCs and 14 (38.9%) were renal lymphomas. All SUV metrics were higher for renal lymphomas than for RCCs (p < 0.0001, for all). All renal lymphomas had an SUVmax higher than 5.98 g/mL (median, 10.99 g/mL), whereas all RCCs had an SUVmax lower than 5.26 g/mL (median, 2.91 g/mL). No statistically significant differences in mass size or margins were found between RCCs and renal lymphoma. CONCLUSION. PET/CT features may be useful for differentiating RCCs from renal involvement in patients with lymphoma with solid renal masses. © American Roentgen Ray Society.
Keywords: adult; aged, 80 and over; middle aged; sensitivity and specificity; radiopharmaceuticals; reproducibility; reproducibility of results; image interpretation, computer-assisted; diagnosis, differential; differential diagnosis; diagnostic imaging; renal cell carcinoma; kidney carcinoma; kidney neoplasms; kidney tumor; carcinoma, renal cell; computer assisted diagnosis; image enhancement; lymphoma; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; radiopharmaceutical agent; pet; ct; procedures; very elderly; cancer; humans; human; male; female; positron emission tomography-computed tomography; positron emission tomography computed tomography
Journal Title: American Journal of Roentgenology
Volume: 208
Issue: 4
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 2017-04-01
Start Page: 849
End Page: 853
Language: English
DOI: 10.2214/ajr.16.17133
PUBMED: 28095016
PROVIDER: scopus
PMCID: PMC5548005
DOI/URL:
Notes: Article -- Export Date: 2 May 2017 -- Source: Scopus
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MSK Authors
  1. Evis Sala
    95 Sala
  2. Heiko Schoder
    289 Schoder
  3. Hedvig Hricak
    333 Hricak
  4. Anita Kumar
    52 Kumar
  5. Debra Alyssa Goldman
    97 Goldman