Use of an ACE inhibitor or angiotensin receptor blocker is a major risk factor for dehydration requiring readmission in the setting of a new ileostomy Journal Article


Authors: Charak, G.; Kuritzkes, B. A.; Al-Mazrou, A.; Suradkar, K.; Valizadeh, N.; Lee-Kong, S. A.; Feingold, D. L.; Pappou, E. P.
Article Title: Use of an ACE inhibitor or angiotensin receptor blocker is a major risk factor for dehydration requiring readmission in the setting of a new ileostomy
Abstract: Purpose: Diverting ileostomies help prevent major complications related to anastomoses after colorectal resection but can cause metabolic derangement and hypovolemia, leading to readmission. This paper aims to determine whether angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use increased the risk of readmission, or readmission specifically for dehydration after new ileostomy creation. Methods: Retrospective analysis of patients undergoing diverting ileostomy at a tertiary-care hospital, 2009–2015. Primary outcome was 60-day readmission for dehydration; secondary outcomes included 60-day readmission for any cause, or for infection obstruction. Results: Ninety-nine patients underwent diverting ileostomy creation, 59% with a primary diagnosis of colorectal cancer. The 60-day readmission rate was 36% (n = 36). Of readmitted patients, 39% (n = 14) were admitted for dehydration. Other readmission reasons were infection (33%) and obstruction (3%). The majority (64%, n = 9) of patients readmitted for dehydration were taking either an ACEi or an ARB. Compared to patients not readmitted for dehydration, those who were readmitted for dehydration were more likely to be on an ACEi or an ARB (11/85, 13% vs. 9/14, 64%). After controlling for covariates, ACEi or ARB use was significantly associated with risk of readmission (p < 0.0001, odds ratio = 13.56, 95% confidence interval 3.54–51.92,). No other diuretic agent was statistically associated with readmission for dehydration. Conclusions: ACEi and ARB use is a significant risk factor for readmission for dehydration following diverting ileostomy creation. Consideration should be given to withholding these medications after ileostomy creation to reduce this risk. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords: dehydration; readmission; diverting ileostomy; angiotensin receptor blocker; angiotensin-converting enzyme inhibitor
Journal Title: International Journal of Colorectal Disease
Volume: 33
Issue: 3
ISSN: 0179-1958
Publisher: Springer  
Date Published: 2018-03-01
Start Page: 311
End Page: 316
Language: English
DOI: 10.1007/s00384-017-2961-y
PROVIDER: scopus
PUBMED: 29374802
DOI/URL:
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Emmanouil Pappou
    4 Pappou