Imaging of human epidermal growth factor receptors for patient selection and response monitoring – From PET imaging and beyond Journal Article
| Authors: | Pereira, P. M. R.; Abma, L.; Henry, K. E.; Lewis, J. S. |
| Article Title: | Imaging of human epidermal growth factor receptors for patient selection and response monitoring – From PET imaging and beyond |
| Abstract: | The Human Epidermal Growth Factor Receptor (ErbB/HER) family - EGFR/HER1, ErbB-2/HER2, ErbB-3/HER3, and ErbB-4/HER4 - play a key role in tumor development. Moreover, positive status of HER2 and specific mutations of EGFR are necessary to initiate HER2 directed and EGFR mutation directed therapies. The status of these receptors is usually determined by assaying biopsy specimens of tumor tissues; however, tissue samples are insufficient to account for the complex dynamics and heterogeneity involved in HER status. Molecular imaging of receptors of the HER family have undergone much development, and some show promise for facilitating patient selection for HER therapy and monitoring of treatment response. This review provides a general overview of HER family expression and signaling in tumor tissue and more importantly discusses the available EGFR, HER2 and HER3 molecular imaging modalities, highlighting their use not only for selecting patients for receptor-targeted therapy, but also for monitoring therapeutic response. Additionally, the design and the biological evaluation of HER-specific imaging probes using different cancer models and clinical data are discussed. © 2018 Elsevier B.V. |
| Keywords: | immunohistochemistry; signal transduction; protein expression; treatment response; nonhuman; patient selection; drug approval; nuclear magnetic resonance imaging; positron emission tomography; cancer diagnosis; protein function; colorectal cancer; protein analysis; reverse transcription polymerase chain reaction; epidermal growth factor receptor; epidermal growth factor receptor 2; molecular dynamics; patient monitoring; molecular imaging; cetuximab; cancer therapy; carcinogenesis; monoclonal antibody; panitumumab; drug receptor binding; fluorescence in situ hybridization; echography; short survey; cancer tissue; protein family; epidermal growth factor receptor 3; ligand binding; molecular probe; imaging and display; fluorescence imaging; epidermal growth factor receptor kinase inhibitor; protein polymorphism; non small cell lung cancer; molecularly targeted therapy; single photon emission computed tomography; photoacoustic tomography; afatinib; human; priority journal; near infrared fluorescence imaging; osimertinib; her dynamics; her heterogeneity; multiplexed imaging; multispectral photoacoustic tomography; raman encoded molecular imaging |
| Journal Title: | Cancer Letters |
| Volume: | 419 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2018-04-10 |
| Start Page: | 139 |
| End Page: | 151 |
| Language: | English |
| DOI: | 10.1016/j.canlet.2018.01.052 |
| PROVIDER: | scopus |
| PUBMED: | 29414302 |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 1 March 2018 -- Source: Scopus |
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