Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth Journal Article
| Authors: | Agus, D. B.; Akita, R. W.; Fox, W. D.; Lewis, G. D.; Higgins, B.; Pisacane, P. I.; Lofgren, J. A.; Tindell, C.; Evans, D. P.; Maiese, K.; Scher, H. I.; Sliwkowski, M. X. |
| Article Title: | Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth |
| Abstract: | ErbB2 is a ligand-less member of the ErbB receptor family that functions as a coreceptor with EGFR, ErbB3, and ErbB4. Here, we describe an approach to target ErbB2's role as a coreceptor using a monoclonal antibody, 2C4, which sterically hinders ErbB2's recruitment into ErbB ligand complexes. Inhibition of ligand-dependent ErbB2 signaling by 2C4 occurs in both low- and high-ErbB2-expressing systems. Since the ErbB3 receptor contains an inactive tyrosine kinase domain, 2C4 is very effective in blocking heregulin-mediated ErbB3-ErbB2 signaling. We demonstrate that the in vitro and in vivo growth of several breast and prostate tumor models is inhibited by 2C4 treatment. Copyright © 2002 Cell Press. |
| Keywords: | signal transduction; cancer survival; controlled study; protein expression; human cell; genetics; androgen; nonhuman; antineoplastic agents; note; antineoplastic agent; animal cell; mouse; animal; metabolism; animals; mice; animal tissue; gene targeting; cell division; gene overexpression; epidermal growth factor receptor; epidermal growth factor receptor 2; animal experiment; animal model; protein binding; drug effect; pathology; tumor cells, cultured; breast neoplasms; time; time factors; monoclonal antibody; prostatic neoplasms; gene expression regulation; gene expression regulation, neoplastic; immunology; antibodies, monoclonal; drug antagonism; xenograft; cell culture; messenger rna; rna, messenger; breast tumor; prostate tumor; ligand; transplantation, heterologous; ligands; receptor, erbb-2; neoplasm transplantation; tumor growth; trastuzumab; epidermal growth factor receptor 3; ligand binding; androgens; receptor binding; stereochemistry; pertuzumab; multigene family; epidermal growth factor receptor 4; cancer transplantation; neu differentiation factor; neuregulin-1; receptor, erbb-3; humans; human; male; female; priority journal; article |
| Journal Title: | Cancer Cell |
| Volume: | 2 |
| Issue: | 2 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2002-08-01 |
| Start Page: | 127 |
| End Page: | 137 |
| Language: | English |
| DOI: | 10.1016/s1535-6108(02)00097-1 |
| PUBMED: | 12204533 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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