Historical perspective of eukaryotic DNA replication Journal Article
| Author: | Kelly, T. |
| Article Title: | Historical perspective of eukaryotic DNA replication |
| Abstract: | The replication of the genome of a eukaryotic cell is a complex process requiring the ordered assembly of multiprotein replisomes at many chromosomal sites. The process is strictly controlled during the cell cycle to ensure the complete and faithful transmission of genetic information to progeny cells. Our current understanding of the mechanisms of eukaryotic DNA replication has evolved over a period of more than 30 years through the efforts of many investigators. The aim of this perspective is to provide a brief history of the major advances during this period. © 2017, Springer Nature Singapore Pte Ltd. |
| Keywords: | protein phosphorylation; nonhuman; dna replication; dna synthesis; protein domain; protein analysis; protein degradation; protein protein interaction; protein binding; enzyme activity; dna; saccharomyces cerevisiae; antigen detection; escherichia coli; plasmid; progeny; dna structure; helicase; catalysis; bacterial genome; eukaryotic cell; sequence homology; virus genome; genomic dna; eukaryote; dna topoisomerase; xenopus laevis; transcription elongation; x ray diffraction; dna fragmentation; dna directed dna polymerase delta; dna directed dna polymerase epsilon; replisome; minichromosome maintenance protein 2; minichromosome maintenance protein 7; prokaryote; single stranded dna binding protein; eukaryotes; prereplicative complex; priority journal; origin of dna replication; initiator; viral models |
| Journal Title: | Advances in Experimental Medicine and Biology |
| Volume: | 1042 |
| ISSN: | 0065-2598 |
| Publisher: | Springer |
| Date Published: | 2017-01-01 |
| Start Page: | 1 |
| End Page: | 41 |
| Language: | English |
| DOI: | 10.1007/978-981-10-6955-0_1 |
| PROVIDER: | scopus |
| PUBMED: | 29357051 |
| DOI/URL: | |
| Notes: | Chapter 1 in "DNA Replication: From Old Principles to New Discoveries" (ISBN: 978-981-10-6954-3) -- Export Date: 1 March 2018 -- Source: Scopus |
