Locoregional therapies for hepatocellular carcinoma and the new LI-RADS treatment response algorithm Journal Article

   


Authors: Kielar, A.; Fowler, K. J.; Lewis, S.; Yaghmai, V.; Miller, F. H.; Yarmohammadi, H.; Kim, C.; Chernyak, V.; Yokoo, T.; Meyer, J.; Newton, I.; Do, R. K.
Article Title: Locoregional therapies for hepatocellular carcinoma and the new LI-RADS treatment response algorithm
Abstract: Radiologists play a central role in the assessment of patient response to locoregional therapies for hepatocellular carcinoma (HCC). The identification of viable tumor following treatment guides further management and potentially affects transplantation eligibility. Liver Imaging Reporting and Data Systems (LI-RADS) first introduced the concept of LR-treated in 2014, and a new treatment response algorithm is included in the 2017 update to assist radiologists in image interpretation of HCC after locoregional therapy. In addition to offering imaging criteria for viable and nonviable HCC, new concepts of nonevaluable tumors as well as tumors with equivocal viability are introduced. Existing guidelines provided by response evaluation criteria in solid tumors (RECIST) and modified RECIST address patient-level assessments and are routinely used in clinical trials but do not address the variable appearances following different locoregional therapies. The new LI-RADS treatment response algorithm addresses this gap and offers a comprehensive approach to assess treatment response for individual lesions after a variety of locoregional therapies, using either contrast-enhanced CT or MRI. © 2017, Springer Science+Business Media, LLC.
Keywords: treatment response; hepatocellular carcinoma; chemoembolization; liver cell carcinoma; liver transplantation; cancer radiotherapy; antineoplastic agent; practice guideline; cancer therapy; radiologist; algorithm; high intensity focused ultrasound; recist; response; liver resection; external beam radiotherapy; radiofrequency ablation; dynamic contrast-enhanced magnetic resonance imaging; contrast-enhanced ultrasound; locoregional therapy; response evaluation criteria in solid tumors; human; priority journal; article; li-rads; microwave thermotherapy
Journal Title: Abdominal Radiology
Volume: 43
Issue: 1
ISSN: 2366-004X
Publisher: Springer  
Date Published: 2018-01-01
Start Page: 218
End Page: 230
Language: English
DOI: 10.1007/s00261-017-1281-6
PROVIDER: scopus
PMCID: PMC5771991
PUBMED: 28780679
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026834463&doi=10.1007%2fs00261-017-1281-6&partnerID=40&md5=cbb70a333705c76f55eade20dfe32c3e
Notes: Article -- Export Date: 6 February 2018 -- Source: Scopus
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MSK Authors
  1. Kinh Gian Do
    256 Do
  2. Hooman Yarmohammadi
    131 Yarmohammadi
  3. Shireen Lewis
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