Genotyping natural killer immune checkpoints to discover biomarkers of response Journal Article


Authors: Cheung, N. K.; Hsu, K. C.
Article Title: Genotyping natural killer immune checkpoints to discover biomarkers of response
Abstract: Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural killer cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome. © 2017 AACR.
Keywords: antigen expression; biological marker; genotype; protein interaction; cellular immunity; immunotherapy; neuroblastoma cell; molecular recognition; natural killer cell; killer cell immunoglobulin like receptor; hla antigen; hla system; tumor microenvironment; cancer immunology; gene linkage disequilibrium; human; priority journal; article
Journal Title: Clinical Cancer Research
Volume: 24
Issue: 1
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2018-01-01
Start Page: 3
End Page: 5
Language: English
DOI: 10.1158/1078-0432.ccr-17-2884
PROVIDER: scopus
PMCID: PMC5754255
PUBMED: 29122934
DOI/URL:
Notes: Article -- Export Date: 1 February 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Nai-Kong Cheung
    439 Cheung
  2. Katharine C Hsu
    133 Hsu