Hepatic angiosarcomatous transformation of a mediastinal germinal cell tumor: A care case report Journal Article
| Authors: | Corrias, G.; Escalon, J. G.; Tang, L.; Monti, S.; Saba, L.; Mannelli, L. |
| Article Title: | Hepatic angiosarcomatous transformation of a mediastinal germinal cell tumor: A care case report |
| Abstract: | Rationale: Mediastinal nonseminomatous germ cell tumor (NSGCT) is an uncommon entity. Metastatic hepatic sarcomatous transformation is rare. Patient concerns: We report a 24-year-old man with no previous related medical history presented with chest pain and left arm numbness. Diagnoses: The X-ray showed an anterior mediastinal mass. The chest computed tomography (CT) confirmed the presence of a mildly enhancing mass in the same location, without invasion of any vascular structure. A CT-guided biopsy was performed, revealing a primary mediastinal nonseminomatous germ cell tumor (NSGCT), yolk sac histology, with areas of somatic transformation to malignant nerve sheath tumor. After surgery patient was followed-up with imaging. Two years later a CT scan showed a new hepatic hyper vascular lesion, confirmed by a subsequent magnetic resonance imaging (MRI) and positron emission tomography (PET) scan. A CT-guided biopsy revealed a hepatic metastatic transformation to angiosarcoma of the primitive NSGCT. Interventions: The patient went on to received palliative chemotherapy. Outcomes: The patient is being followed-up regularly at the outpatient department. Lessons: Because of the potential of metastatic sarcoma arising from germ cell tumors, these patients should undergo periodical follow-up, with periodical scans. PET\CT scan might have a role in the follow-up of these patients. © 2017 the Author(s). |
| Keywords: | adult; clinical article; human tissue; cancer surgery; young adult; histopathology; paresthesia; case report; cisplatin; cancer combination chemotherapy; paclitaxel; nuclear magnetic resonance imaging; follow up; cancer palliative therapy; metastasis; computer assisted tomography; multiple cycle treatment; tumor volume; angiosarcoma; ifosfamide; abdominal pain; liver metastasis; thorax pain; image subtraction; thorax radiography; eosin; hematoxylin; cancer control; mesna; malignant transformation; germ cell tumor; mediastinum tumor; yolk sac tumor; fluorodeoxyglucose; cancer morphology; liver injury; transformation; surgical margin; mediastinum mass; 18f-fdg pet/ct; antimetastatic agent; image guided biopsy; mediastinal; human; male; priority journal; article; mediastinum lymphadenopathy; positron emission tomography-computed tomography; appendix disease; epiploic appendagitis; nerve sheath cancer |
| Journal Title: | Medicine |
| Volume: | 96 |
| Issue: | 51 |
| ISSN: | 0025-7974 |
| Publisher: | Wolters Kluwer Health, Inc |
| Date Published: | 2017-12-01 |
| Start Page: | e9152 |
| Language: | English |
| DOI: | 10.1097/md.0000000000009152 |
| PROVIDER: | scopus |
| PMCID: | PMC5758148 |
| PUBMED: | 29390446 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work