Advances in therapies for non-Hodgkin lymphoma in children Journal Article
| Authors: | Kobos, R.; Terry, W. |
| Article Title: | Advances in therapies for non-Hodgkin lymphoma in children |
| Abstract: | Pediatric patients with newly diagnosed, non-Hodgkin Lymphoma (NHL) have an excellent overall survival. However, therapy regimens are associated with acute toxicity and late effects. Furthermore, patients with relapsed or refractory disease have relatively few options with proven clinical benefit. Both histologic and molecular differences exist between adult and pediatric NHL preventing simple translation of adult NHL successes into improvements in pediatric NHL treatment. This review summarizes the introduction of targeted therapies into frontline treatments for patients with anaplastic large-cell lymphoma and CD20-positive tumors, with the goal of improving overall survival while limiting both short-and long-term toxicities. In addition, newer approaches that have limited data in children but may have a significant role in how we treat pediatric NHL in the future are reviewed, which include CD19 directed therapy, Notch inhibition, the tri-functional antibody, FBTA05, and EZH2 inhibition. |
| Keywords: | cancer chemotherapy; unclassified drug; overall survival; review; drug targeting; rituximab; notch receptor; childhood cancer; monoclonal antibody; cd20 antigen; nonhodgkin lymphoma; chimeric antigen receptor; cd19 antigen; gamma secretase inhibitor; transcription factor ezh2; phase 2 clinical trial (topic); phase 3 clinical trial (topic); anaplastic large cell lymphoma; crizotinib; brentuximab vedotin; blinatumomab; human; denintuzumab mafodotin; fbta05 |
| Journal Title: | Hematology-American Society of Hematology Education Program |
| Volume: | 2015 |
| Issue: | 1 |
| ISSN: | 1520-4391 |
| Publisher: | American Society of Hematology |
| Date Published: | 2015-12-05 |
| Start Page: | 522 |
| End Page: | 528 |
| Language: | English |
| DOI: | 10.1182/asheducation-2015.1.522 |
| PROVIDER: | scopus |
| PUBMED: | 26637768 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 February 2018 -- Source: Scopus |
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