Pathophysiology of erectile dysfunction following radiation therapy Journal Article
| Authors: | Croog, V. J.; Zelefsky, M. J. |
| Article Title: | Pathophysiology of erectile dysfunction following radiation therapy |
| Abstract: | The development of erectile dysfunction (ED) after definitive prostate radiotherapy is multi-factorial in nature, and the major pathophysiologic injuries differ from those that affect patients after radical prostatectomy (RP). There is now compelling evidence that endothelial cell damage in nearby erectile tissue as a direct result of radiotherapy contributes significantly to the relatively delayed onset of post-treatment ED. Conversely, the injury to the neurovascular bundles that is central to the onset of ED after RP does not appear to be a major causative force in the setting of radiotherapy. Whether damage to the penile bulb contributes to the onset of radiation-associated impotence (RAI) is highly controversial and remains unclear. This review will examine the various functional and observational studies that have helped to highlight the injuries relevant to the development of RAI. |
| Keywords: | irradiation; brachytherapy; external beam radiotherapy; impotence; ionizing-radiation; molecules; adhesion; dysfunction; localized prostate-cancer; sildenafil citrate; prostate radiation; 3-dimensional conformal radiotherapy; erectile; neurovascular bundles; penile bulb; vascular damage |
| Journal Title: | Current Clinical Urology |
| ISSN: | 2197-7194 |
| Publisher: | Humana Press Inc |
| Date Published: | 2009-01-01 |
| Start Page: | 55 |
| End Page: | 67 |
| Language: | English |
| ACCESSION: | WOS:000267013600004 |
| PROVIDER: | wos |
| DOI: | 10.1007/978-1-60327-555-2_4 |
| Notes: | Chapter 4 in "Sexual Function in the Prostate Cancer Patient" (ISBN: 978-1-60327-554-5) -- 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA -- Source: Wos |
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