The role and structure of a postradical prostatectomy penile rehabilitation program Journal Article
| Author: | Mulhall, J. P. |
| Article Title: | The role and structure of a postradical prostatectomy penile rehabilitation program |
| Abstract: | Erectile dysfunction (ED) is common after radical prostatectomy (RP). ED has a negative impact on health-related quality of life. Penile rehabilitation is defined as the use of any drug or device at or after RP to maximize erectile function recovery. The purpose of penile rehabilitation is the prevention of corpus cavernosal smooth muscle structural alterations not only to maximize the chances of a man having recovery of functional erections but also returning him to his preoperative erectile function level. Appreciating the value of penile rehabilitation requires understanding five concepts: the pathophysiology of ED after RP, cavernosal oxygenation, venous leak, and both the animal and human data supporting this strategy. This paper gives an overview of these factors and attempts to give a common-sense, practical guide to a rehabilitation program. © 2009 Current Medicine Group, LLC. |
| Keywords: | treatment response; recovery of function; clinical trial; review; placebo; dose response; drug dose comparison; drug dose reduction; drug withdrawal; nonhuman; treatment duration; pathophysiology; postoperative care; follow up; low drug dose; quality of life; apoptosis; pain; transforming growth factor beta; postoperative complication; prostatic neoplasms; cost effectiveness analysis; drug cost; health care cost; health insurance; prostatectomy; evening dosage; collagen; long term care; patient compliance; cyclic amp; nerve injury; optimal drug dose; drug blood level; corpus cavernosum; drug dose titration; erectile dysfunction; convalescence; hyperlipidemia; phosphodiesterase v inhibitor; prostaglandin e1; sildenafil; tadalafil; vardenafil; sexual intercourse; penis erection; penis artery; penis; artery injury; catheter removal; collagen synthesis; device therapy; endothelial dysfunction; muscle injury; penis pain; protein synthesis inhibition; rehabilitation medicine; smooth muscle; tissue oxygenation; urethral pain; vacuum assisted closure |
| Journal Title: | Current Urology Reports |
| Volume: | 10 |
| Issue: | 3 |
| ISSN: | 1527-2737 |
| Publisher: | Springer |
| Date Published: | 2009-05-01 |
| Start Page: | 219 |
| End Page: | 225 |
| Language: | English |
| DOI: | 10.1007/s11934-009-0037-4 |
| PUBMED: | 19371480 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "Source: Scopus" |
