Multifunctional molecular imaging probes for estrogen receptors: (99m)Tc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP) Journal Article
| Authors: | Moharrami, P.; Unak, P.; Guldu, O. K.; Medine, E. I.; Gumuser, G.; Bilgin, E. S.; Aras, O. |
| Article Title: | Multifunctional molecular imaging probes for estrogen receptors: (99m)Tc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP) |
| Abstract: | A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies. © 2017, Akadémiai Kiadó, Budapest, Hungary. |
| Keywords: | controlled study; nonhuman; technetium 99m; mass spectrometry; breast cancer; animal experiment; lung cancer; in vivo study; drug effect; molecular imaging; prostate cancer; isotope labeling; cellular distribution; diethylstilbestrol; drug cytotoxicity; estrogen receptor; drug determination; quantum dot; lipophilicity; cancer imaging; female; article; mcf-7 cell line; quantum dot nanoparticles; a-549 cell line; new zealand rabbit; pc-3 [human prostate carcinoma] cell line |
| Journal Title: | Journal of Radioanalytical and Nuclear Chemistry |
| Volume: | 314 |
| Issue: | 3 |
| ISSN: | 0236-5731 |
| Publisher: | Springer |
| Date Published: | 2017-12-01 |
| Start Page: | 2609 |
| End Page: | 2620 |
| Language: | English |
| DOI: | 10.1007/s10967-017-5630-2 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
