Intracardiac low-grade sarcoma following treatment for Ewing sarcoma Journal Article
| Authors: | Ortiz, M. V.; Magnan, H.; Slotkin, E. K.; Ambati, S. R.; Chou, A. J.; Wexler, L. H.; Meyers, P. A.; Walsh, M. F.; Heaton, T.; Girardi, L. N.; Wolden, S. L.; Price, A. P.; Kennedy, J. A.; Zehir, A.; Hameed, M.; Berger, M. F.; Kentsis, A.; Shukla, N. |
| Article Title: | Intracardiac low-grade sarcoma following treatment for Ewing sarcoma |
| Abstract: | A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity. © 2017 Wolters Kluwer Health, Inc. |
| Keywords: | adolescent; genetics; mutation; case report; antineoplastic agent; antineoplastic combined chemotherapy protocols; tomography, x-ray computed; biopsy; ewing sarcoma; sarcoma; rna binding protein; rna-binding proteins; genomics; neoplasms, second primary; second cancer; calmodulin binding protein; ewsr1 protein, human; calmodulin-binding proteins; complication; heart neoplasms; sarcoma, ewing; humans; human; male; low-grade sarcoma; x-ray computed tomography; cell-free dna; cardiac sarcoma |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 39 |
| Issue: | 8 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2017-11-01 |
| Start Page: | e443 |
| End Page: | e445 |
| Language: | English |
| DOI: | 10.1097/mph.0000000000000754 |
| PUBMED: | 28060130 |
| PROVIDER: | scopus |
| PMCID: | PMC5498269 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
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