Intracardiac low-grade sarcoma following treatment for Ewing sarcoma Journal Article


Authors: Ortiz, M. V.; Magnan, H.; Slotkin, E. K.; Ambati, S. R.; Chou, A. J.; Wexler, L. H.; Meyers, P. A.; Walsh, M. F.; Heaton, T.; Girardi, L. N.; Wolden, S. L.; Price, A. P.; Kennedy, J. A.; Zehir, A.; Hameed, M.; Berger, M. F.; Kentsis, A.; Shukla, N.
Article Title: Intracardiac low-grade sarcoma following treatment for Ewing sarcoma
Abstract: A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity. © 2017 Wolters Kluwer Health, Inc.
Keywords: adolescent; genetics; mutation; case report; antineoplastic agent; antineoplastic combined chemotherapy protocols; tomography, x-ray computed; biopsy; ewing sarcoma; sarcoma; rna binding protein; rna-binding proteins; genomics; neoplasms, second primary; second cancer; calmodulin binding protein; ewsr1 protein, human; calmodulin-binding proteins; complication; heart neoplasms; sarcoma, ewing; humans; human; male; low-grade sarcoma; x-ray computed tomography; cell-free dna; cardiac sarcoma
Journal Title: Journal of Pediatric Hematology/Oncology
Volume: 39
Issue: 8
ISSN: 1077-4114
Publisher: Lippincott Williams & Wilkins  
Date Published: 2017-11-01
Start Page: e443
End Page: e445
Language: English
DOI: 10.1097/mph.0000000000000754
PUBMED: 28060130
PROVIDER: scopus
PMCID: PMC5498269
DOI/URL:
Notes: Article -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Anita P Price
    35 Price
  2. Meera Hameed
    152 Hameed
  3. Suzanne L Wolden
    438 Wolden
  4. Leonard H Wexler
    140 Wexler
  5. Alexander Ja-Ho Chou
    55 Chou
  6. Srikanth Reddy Ambati
    27 Ambati
  7. Ahmet Zehir
    169 Zehir
  8. Michael Forman Berger
    434 Berger
  9. Paul Meyers
    256 Meyers
  10. Neerav Shukla
    76 Shukla
  11. Heather Magnan
    25 Magnan
  12. Emily Kanaya Slotkin
    16 Slotkin
  13. Todd Erin Heaton
    19 Heaton
  14. Alex   Kentsis
    60 Kentsis
  15. Michael Francis Walsh
    52 Walsh
  16. Michael Vincent Ortiz
    13 Ortiz