Current concepts in (68)Ga-DOTATATE imaging of neuroendocrine neoplasms: Interpretation, biodistribution, dosimetry, and molecular strategies Journal Article
| Authors: | Bodei, L.; Ambrosini, V.; Herrmann, K.; Modlin, I. |
| Article Title: | Current concepts in (68)Ga-DOTATATE imaging of neuroendocrine neoplasms: Interpretation, biodistribution, dosimetry, and molecular strategies |
| Abstract: | 68Ga-DOTATATE PET/CT provides information on the location of somatostatin receptor–expressing tumors. Integrating this imaging data effectively in patient care requires the clinical history; the histopathology and biomarker information; and the grade, stage, and prior imaging results. Previous therapies and technical aspects of the study should be considered, given their ability to alter the interpretation of the images. This includes physiologic biodistribution of the radiotracer, as well as conditions that engender false-positive results. This article provides a guide to the performance and interpretation of 68Ga-DOTATATE PET/CT and describes its role in the diagnostic algorithm of neuroendocrine neoplasms and its overall utility in their management. COPYRIGHT © 2017 by the Society of Nuclear Medicine and Molecular Imaging. |
| Keywords: | unclassified drug; cancer staging; diagnostic accuracy; radiopharmaceuticals; biological marker; image analysis; image interpretation, computer-assisted; practice guideline; diagnostic imaging; oncology; neuroendocrine tumor; tissue distribution; computer assisted diagnosis; diagnostic value; dosimetry; image quality; radioactivity; peptides; radiopharmaceutical agent; false positive result; false positive reactions; organometallic compound; organometallic compounds; somatostatin derivative; neuroendocrine tumors; classification algorithm; somatostatin receptor; radioisotope distribution; neuroendocrine; biodistribution; molecular diagnosis; endocrine; radiation absorption; humans; human; priority journal; article; positron emission tomography-computed tomography; positron emission tomography computed tomography; gallium dotatate ga 68; 68ga-dotatate; gallium dotanoc ga 68; gallium dotatoc ga 68; dotatate gallium ga-68; effective dose (radiation) |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 58 |
| Issue: | 11 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2017-11-01 |
| Start Page: | 1718 |
| End Page: | 1726 |
| Language: | English |
| DOI: | 10.2967/jnumed.116.186361 |
| PUBMED: | 28818983 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
