Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood? Journal Article
| Authors: | Dunkel, I. J.; O'Malley, B.; Finlay, J. L. |
| Article Title: | Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood? |
| Abstract: | Diffuse pontine tumors are highly lethal and conventional therapy with irradiation provides long-term survival to a very small proportion of the patients. We have reported promising results using high-dose chemotherapy with autologous stem cell rescue in patients with recurrent high-grade astrocytomas in other anatomic locations, but our results and those of others have been very discouraging in children with brain stem tumors. Alternative strategies need to be developed for this highly lethal disease. © 1996 S. Karger AG, Basel. |
| Keywords: | adult; child; survival rate; conference paper; chemotherapy; carboplatin; etoposide; radiotherapy; cyclophosphamide; dose-response relationship, drug; thiotepa; stem cell; antiinfective agent; infant; newborn; brain stem tumor; cerebellar neoplasms; astrocytoma; cell transplantation; humans; human; female; priority journal; cerebellopontine angle; stem cell rescue, autologous |
| Journal Title: | Pediatric Neurosurgery |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 1016-2291 |
| Publisher: | Karger |
| Date Published: | 1996-01-01 |
| Start Page: | 263 |
| End Page: | 266 |
| Language: | English |
| DOI: | 10.1159/000121049 |
| PUBMED: | 8933570 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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