Vancomycin-resistant Enterococcus faecium on a pediatric oncology ward: Duration of stool shedding and incidence of clinical infection Journal Article
| Authors: | Henning, K. J.; Delencastre, H.; Eagan, J.; Boone, N.; Brown, A.; Chung, M.; Wollner, N.; Armstrong, D. |
| Article Title: | Vancomycin-resistant Enterococcus faecium on a pediatric oncology ward: Duration of stool shedding and incidence of clinical infection |
| Abstract: | Objective. To determine the duration of stool shedding and incidence of clinical infection among pediatric oncology patients colonized with vancomycin-resistant Enterococcus faecium (VRE) in our institution. Methods. Stool cultures were obtained from all patients admitted from May 15 to August 2, 1994. Patients were followed for evidence of clinical VRE infection and surveillance stool results through August 15, 1995. Genetic relatedness of stool-clinical isolate pairs and serial stool samples was evaluated using pulsed field gel electrophoresis. Results. Twenty-three (32%) of 73 screened patients were colonized with VRE. Eight (35%) of the colonized patients cleared VRE from stool; 10 (43%) were persistent carriers, excreting organisms for 19 to 331 days (median, 112 days); and 5 patients had an insufficient number of stools to determine length of carriage. Persistent carriers had a median of 6 hospital readmissions; 8 of 10 were positive at first or second readmission. Clinical VRE infection developed in 6 of 73 patients (annual incidence, 8.2%). Clinical cases had more days of neutropenia between colonization and infection than colonized patients during a comparable follow-up (49 vs. 16 days, P = 0.04). Five of 6 stool-clinical isolate pairs were identical by pulsed field gel electrophoresis. Serial stools from 6 of 7 patients (collected 20 to 343 days apart) were identical by pulsed field gel electrophoresis. |
| Keywords: | child; clinical article; neutropenia; neoplasms; incidence; risk factors; oncology; antibiotic resistance; anti-bacterial agents; oncology service, hospital; vancomycin resistance; bacterial colonization; hospital infection; gram-positive bacterial infections; vancomycin; infection control; feces; colonization; feces analysis; pediatrics; electrophoresis, gel, pulsed-field; enterococcus faecium; excretion; drug resistance, microbial; enterococcus faecalis; disease carrier; humans; human; male; female; priority journal; article; carrier state |
| Journal Title: | Pediatric Infectious Disease Journal |
| Volume: | 15 |
| Issue: | 10 |
| ISSN: | 0891-3668 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1996-10-01 |
| Start Page: | 848 |
| End Page: | 854 |
| Language: | English |
| DOI: | 10.1097/00006454-199610000-00004 |
| PUBMED: | 8895914 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work