Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5 Journal Article
| Authors: | Kleef, R.; Delohery, T. M.; Bovbjerg, D. H. |
| Article Title: | Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5 |
| Abstract: | Human peripheral blood mononuclear cells from healthy donors were treated ex vivo with the proteolytic enzyme bromelain and studied by flow cytometry. Bromelain-treated lymphocytes exhibited 60–90% reduced cell surface staining for CD44 and CD62-L molecules. While the staining for molecules CD 16, CD56 and CD49d was unaffected, a moderate increase (10–40%) in expression of the β2-integrins CD1 la-c was seen. This selective modulation of cell adhesion molecules (CAM) was seen on T cells and NK cells, as well. The selective modulation of CAM may help explain some of the clinical effects observed after bromelain treatment in patients suffering from chronic inflammatory disease, HIV and cancer. © 1996 S. Karger AG, Basel. |
| Keywords: | adult; controlled study; human cell; flow cytometry; human immunodeficiency virus infection; t lymphocyte; antigens, cd3; cd16 antigen; mononuclear cell; cd11b antigen; natural killer cell; cell adhesion molecules; receptors, igg; human immunodeficiency virus; proteinase; hermes antigen; lymphocytes; integrin; chronic inflammation; normal human; cell adhesion molecule; cell surface; padgem protein; lymphocyte subsets; antigens, cd44; cd56 antigen; bromelain; bromelains; lymphocyte function associated antigen 1; glycoprotein p 15095; antigens, cd56; antigens, cd18; cancer; humans; human; priority journal; article; proteolytic enzymes |
| Journal Title: | Pathobiology |
| Volume: | 64 |
| Issue: | 6 |
| ISSN: | 1015-2008 |
| Publisher: | S. Karger AG |
| Date Published: | 1996-01-01 |
| Start Page: | 339 |
| End Page: | 346 |
| Language: | English |
| DOI: | 10.1159/000164070 |
| PUBMED: | 9159029 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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