Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease Journal Article
| Authors: | Polydorides, A. D.; Rosenblum, M. K.; Edgar, M. A. |
| Article Title: | Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease |
| Abstract: | A case of metastatic renal cell carcinoma (RCC) to a capillary hemangioblastonna (HAB) of the central nervous system in a 52-year-old woman with von Hippel-Lindau (vHL) syndrome is described. We review the literature on metastatic RCC to HAB, summarize the histologic and immunohistochemical features that can distinguish between the 2 tumors, and comment on the significance of such a finding in terms of the clinical diagnosis of vHL We found the expression of CAM 5.2, RCC antigen, and CD10 to be strong in RCC and absent in HAB and, conversely, staining with Leu-7, neural cell adhesion molecule, and inhibin-α was present in HAB but weak or absent in RCC. These antibodies can be used to differentiate these entities, provided one is astute in recognizing the possibility of their co-existence. |
| Keywords: | immunohistochemistry; adult; human tissue; middle aged; unclassified drug; histopathology; cancer recurrence; case report; disease association; neoplasm recurrence, local; kidney carcinoma; kidney neoplasms; central nervous system tumor; carcinoma, renal cell; family history; spinal cord tumor; nerve cell adhesion molecule; von hippel lindau disease; cerebellar neoplasms; hemangioblastoma; common acute lymphoblastic leukemia antigen; inhibin; cd57 antigen; laminectomy; cervical vertebrae; spinal cord neoplasms; hippel-lindau disease; inhibin alpha |
| Journal Title: | Archives of Pathology & Laboratory Medicine |
| Volume: | 131 |
| Issue: | 4 |
| ISSN: | 0003-9985 |
| Publisher: | College of American Pathologists |
| Date Published: | 2007-04-01 |
| Start Page: | 641 |
| End Page: | 645 |
| Language: | English |
| PUBMED: | 17425399 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: ARPAA" - "Source: Scopus" |
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