Low-grade oligodendroglioma responds to chemotherapy Journal Article
| Authors: | Mason, W. P.; Krol, G. S.; DeAngelis, L. M. |
| Article Title: | Low-grade oligodendroglioma responds to chemotherapy |
| Abstract: | We administered chemotherapy in standard and intensified formulations of procarbazine, lomustine (CCNU), and vincristine to nine symptomatic patients with low-grade oligodendroglioma. Eight patients were treated with chemotherapy at presentation and one was treated for a recurrence after radiotherapy had failed. All patients improved by clinical or MRI criteria, or both. No patient deteriorated while in therapy and the responses were sustained without radiotherapy for a median of 35 months (range, 22-45) in all surviving patients treated at presentation. Chemotherapy was well tolerated; all patients developed myelosuppression, but only those receiving the intensified regimen required dose reduction or premature discontinuation of treatment. As with recurrent and anaplastic oligodendroglioma, low-grade oligodendroglioma responds to chemotherapy. |
| Keywords: | adult; cancer chemotherapy; cancer survival; clinical article; middle aged; cancer radiotherapy; nuclear magnetic resonance imaging; brain neoplasms; magnetic resonance imaging; bone marrow suppression; antineoplastic combined chemotherapy protocols; vincristine; lomustine; procarbazine; oligodendroglioma; humans; human; male; female; priority journal; article |
| Journal Title: | Neurology |
| Volume: | 46 |
| Issue: | 1 |
| ISSN: | 0028-3878 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1996-01-01 |
| Start Page: | 203 |
| End Page: | 207 |
| Language: | English |
| PUBMED: | 8559376 |
| PROVIDER: | scopus |
| DOI: | 10.1212/WNL.46.1.203 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
