Total synthesis and proof of structure of a human breast tumor (globo-H) antigen Journal Article
| Authors: | Park, T. K.; Kim, I. J.; Hu, S.; Bilodeau, M. T.; Randolph, J. T.; Kwon, O.; Danishefsky, S. J. |
| Article Title: | Total synthesis and proof of structure of a human breast tumor (globo-H) antigen |
| Abstract: | The total synthesis of the Hakomori MBr1 antigen, heavily expressed on human breast tumors, is related. The construction involved the assembly of four glycals: (17 (twice), 18, 20, and 26) and an L-fucose derivative, 34. The sensitivity of the stereochemistry of sulfonamido galactosylation by a terminal galactose ring as a function of the state of protection status of its C4 alcohol was exploited in a key step. The synthesis served to confirm the Hakomori assignment of structure, and paves the way for immunoconjugation. |
| Keywords: | breast cancer; in vitro study; antigen; protein synthesis; protein structure; human; article |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 118 |
| Issue: | 46 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 1996-11-20 |
| Start Page: | 11488 |
| End Page: | 11500 |
| Language: | English |
| DOI: | 10.1021/ja962048b |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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